血浆血管性血友病因子抗原、D-二聚体、纤维蛋白原/纤维蛋白降解产物检测在急性脑梗死中的诊断价值

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摘要目的探讨血浆血管性血友病因子抗原（vWF:Ag）、D-二聚体（D-D）、纤维蛋白原/纤维蛋白降解产物（FDP）检测在急性脑梗死中的诊断价值。方法选取2019年4月至2020年12月上海仁济医院宝山分院收治的86 例急性脑梗死患者作为观察组，选取2019年4月至2020年12月上海仁济医院宝山分院60 例健康体检者为对照组。比较两组血浆vWF:Ag、D-D、FDP 浓度；三个指标进行相关性分析；绘制ROC 曲线，分析vWF:Ag、D-D、FDP水平在急性脑梗死患者中的诊断效能并进行logistic 回归分析。结果观察组vWF:Ag、D-D、FDP 水平高于对照组，差异有统计学意义（P＜0.05）。vWF:Ag 与D-D 水平呈正相关（r=0.95，P＜0.05），而vWF:Ag 与FDP、D-D 与FDP无相关性（r=0.54、0.68，P＞0.05）。logistic 回归分析结果显示，vWF:Ag 与D-D 是发生ACI 的相关危险因素（P＜0.05）。结论血浆vWF:Ag、D-D 与FDP 在急性心肌梗死患者检验中具有一定的临床诊断价值，vWF:Ag、D-D 可能是急性脑梗死的危险因素，并作为临床诊断的预测指标。

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	王聚瑾
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关键词 ：脑梗死, 血管性血友病因子抗原, D-二聚体, 纤维蛋白原/纤维蛋白降解产物

Abstract：Objective To explore the plasma the diagnostic value of von Willebrand factor antigen (vWF:Ag), D-dimer(D-D), and fibrinogen/fibrin degradation products (FDP) tests in acute cerebral infarction. Methods Eighty-six cases of patients with acute cerebral infarction admitted to Baoshan Branch of Shanghai Renji Hospital from April 2019 to December 2020 were selected as the observation group, and 86 cases of acute cerebral infarction admitted to Baoshan Branch of Shanghai Renji Hospital from April 2019 to December 2020 were selected as the observation group, and 60 physical examination patients of Baoshan Branch of Shanghai Renji Hospital from April 2019 to December 2020 were selected as the control group. The plasma vWF:Ag, D-D and FDP concentration; three indexes for correlation analysis were compared; draw ROC curve, analyze the diagnostic efficacy of vWF:Ag, D-D and FDP levels in patients with acute cerebral infarction and perform logistic regression analysis. Results The vWF:Ag, D-D, and FDP levels in the observation group were higher than those in the control group, with statistically significant differences (P＜0.05). The vWF:Ag was positively associated with D-D levels (r=0.95, P＜0.05), while the vWF:Ag had no correlation with FDP (r=0.54,P＞0.05), D-D had no correlation with FDP (r=0.68, P＞0.05). The logistic regression analysis showed that the vWF:Ag and D-D were the related risk factors for developing ACI (P＜0.05). Conclusions Plasma vWF:Ag, D-D and FDP have certain clinical diagnostic value in the test of patients with acute myocardial infarction, and vWF:Ag and D-D tests may be risk factors for acute cerebral infarction and serve as predictors of clinical diagnosis.

Key words： Cerebral infarction Von Willebrand factor antigen D-dimer, fibrinogen/fibrin degradation products

引用本文:

王聚瑾;况佳;杨叶怡;徐刚▲. 血浆血管性血友病因子抗原、D-二聚体、纤维蛋白原/纤维蛋白降解产物检测在急性脑梗死中的诊断价值[J]. 中国当代医药, 2022, 29(2): 133-136.
WANG Jujin ;KUANG Jia; YANG Yeyi; XU Gang▲. Plasma the diagnostic value of von Willebrand factor antigen, D-dimer,and fibrinogen/fibrin degradation products tests in acute cerebral infarction. 中国当代医药, 2022, 29(2): 133-136.

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