Abstract：Objective To explore the clinical effect of Ivabradine Tablets combined with Atorvastatin Calcium Tablets in the treatment of patients with carotid atherosclerosis.Methods A total of 84 patients with carotid atherosclerosis admitted to Ganzhou Municipal Hospital from June 2018 to March 2020 were selected as the research objects,and were divided into control group(n=40)and observation group(n=44).The control group was treated with Atorvastatin Calcium Tablets,and the observation group was treated with Ivabradine Tablets combined with Atorvastatin Calcium Tablets.The changes in blood lipid metabolism,inflammation and oxidative stress levels were compared between the two groups.Results After six months of treatment,the total cholesterol(TC),triacylglycerol(TG),low density lipoprotein cholesterin(LDL-C),high density lipoprotein cholesterol(HDL-C)concentration,high sensitivity C-reactive protein(hs-CRP),oxidized low density lipoprotein(ox-LDL)and oxidative stress marker malondialdehyde(MDA)levels of the observation group were lower than those of the control group,and the superoxide dismutase(SOD)level was higher than that of the control group,the differences were statistically significant(P＜0.05).After half a year of treatment,the medial intima thickness(IMT)in the observation group was lower than that of the control group,with statistical difference(P＜0.05).Conclusion Ivabradine Tablets combined with Atorvastatin Calcium Tablets has a prominent effect on blood lipid metabolism,inflammation and oxidative stress in patients with carotid atherosclerosis.It obtains a significant antiatherosclerosis effect and is beneficial to the prevention of cardiovascular and cerebrovascular events.
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