Abstract：Objective To investigate the effect of Compound Guaiacol Potassium Sulfonate Oral Solution on children with acute bronchitis.Methods A total of 84 children with acute bronchitis treated in the Third People′s Hospital of Jingzhou City from January 2019 to January 2020 were selected as the research subjects.According to random number table method,they were divided into control group and observation group,with 42 cases in each group.The control group was given Ribavirin Injection intravenously,and the observation group was given Compound Guaiacol Potassium Sulfonate Oral Solution on this basis.After 10 d of treatment,the differences in efficacy,time of disappearance of clinical symptoms and incidence of adverse drug reactions,as well as the differences in serum inflammatory indexes(C-reactive protein[CRP],interlenkin-6[IL-6]and tumor necrosis factor[TNF]-α)between the two groups before and after 10 d of treatment were compared.Results After 10 d of treatment,the efficacy in the observation group was better than that in control group,and the total clinical effective rate was higher than that in the control group,and the differences were statistically significant(P＜0.05).The disappearance times of cough,high fever,expectoration and lung rales in the observation group were shorter than those in control group(P＜0.05).There was no significant difference in the total incidence rate of adverse drug reactions of gastrointestinal reactions,dizziness and somnolence between the two groups(P＞0.05).Before treatment,there were no significant differences in serum CRP,IL-6 and TNF-α between the two groups(P＞0.05).After 10 d of treatment,CRP,IL-6 and TNF-α in the two groups were lower than those before treatment,and serum CRP,IL-6 and TNF-α in observation group were lower than those in the control group,the differences were statistically significant(P＜0.05).Conclusion Compound Guaiacol Potassium Sulfonate Oral Solution in the adjuvant treatment of children with acute bronchitis is safe,reliable and effective in accelerating the disappearance of clinical symptoms and improving the related indicators of inflammatory factors,which has clinical application value.
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