Objective To explore the influencing factors of the formation of blood hypercoagulability in the patients after laparoscopic cholecystectomy.Methods From March 2015 to March 2017, 80 patients with cholecystitis who underwent laparoscopic cholecystectomy in our hospital were selected as study subjects.Patients were divided into observation group (hypercoagulable state, n=32) and control group (no hypercoagulable state, n=48) according to whether patients had hypercoagulable state after surgery.General information, previous medical history, preoperative systolic blood pressure, blood glucose, high-density lipoprotein cholesterol cholesterol, and low-density lipoprotein cholesterol levels were compared between the two groups.Logistic regression was used to further analyze the risk factors of blood hypercoagulability in patients after laparoscopic cholecystectomy.Results The results of univariate analysis showed that the preoperative systolic blood pressure, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and history of hyperlipidemia of the two groups had statistically significant differences (P<0.05).Multivariate analysis results suggested that history of hyperlipidemia (β=6.96, OR=1.06, 95%CI=0.52-2.17), preoperative systolic blood pressure level ≥128 mmHg (β=3.06, OR=1.28, 95%CI=0.95-2.18), and preoperative low-density lipoprotein cholesterol level≥2.82 mmol/L (β=2.78, OR=1.38, 95%CI=0.63-1.79) were risk factors for the formation of blood hypercoagulability in the patients after laparoscopic cholecystectomy (P<0.05).Conclusion The formation of blood hypercoagulability after laparoscopic cholecystectomy is closely related to preoperative systolic blood pressure, history of hyperlipidemia, preoperative low-density lipoprotein cholesterol, preoperative high-density lipoprotein cholesterol level and other indicators.Corresponding precautions need to be taken to reduce the risk of postoperative blood hypercoagulability.