Objective To explore the clinical effect of Fuyanping Capsules combined with Metronidazole Suppository on vaginal microecology in patients with vaginitis.Methods From January to December 2019, 400 patients with vaginitis received treatment in the Community Health Service Center of Qingxi Town were randomly divided into the observation group (Fuyanping Capsules with Metronidazole Suppository) and the control group (Metronidazole Suppository, with 200 cases in each group.The vaginal microecological indexes and therapeutic effect of the two groups were compared.Results After treatment, the pH value, bacterial density and diversity of vagina in the observation group were better than those in the control group, the differences were statistically significant (P<0.05).The number of lactobacilli in the observation group was higher than that in the control group, the difference was statistically significant (P<0.05).The total effective rate in the observation group (95.50%) was higher than that in the control group (82.50%), the difference was statistically significant (P<0.05).There was no statistically significant difference in the total incidence of adverse reactions of patients between the two groups (P>0.05).After 3 months of follow-up, the relapse rate in the observation group (5.24%) was lower than that in the control group (27.88%), the difference was statistically significant (P<0.05).Conclusion Fuyanping Capsules combined with Metronidazole Suppository for vaginitis can improve the internal environment of the vagina, improve the curative effect, reduce adverse reactions, and prevent disease recurrence.