环状RNA在人类生殖妊娠方面的研究进展

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摘要环状RNA（circRNA）是一种自然存在于生物体内，呈共价闭合环状结构的内源性非编码RNA（ncRNA），具有调控基因表达的重要生物学作用。其通过作为微小RNA（miRNA）在环状RNA-miRNA-mRNA 轴中发挥作用，调节可变剪接以及亲本基因表达。近年来随着技术的发展，人们逐渐发现了具有独特生物学特性的环状RNA 在临床疾病预测、早期干预及诊断治疗等方面具有广阔的发展空间，成为近年的研究热点。但环状RNA 在妇产科非肿瘤方面研究相对较少，故本文简要介绍环状RNA 并对其在人类生殖与妊娠方面非肿瘤相关疾病的研究进展进行概述。

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	赵一燕
	鞠捷
	孔祥

关键词 ：环状RNA, 生殖, 妊娠, 复发性流产, 产前诊断

Abstract：Circular RNA is an endogenous no-coding RNA (ncRNA) that naturally exists in living organisms and has a covalently closed loop structure. It plays an important role in the regulation of gene expression. It acts as microRNA(miRNA) in the circular RNA-miRNA-mRNA axis, regulating alternative splicing and parental gene expression. With the development of technology in recent years, people have gradually discovered that circular RNA with unique biological characteristics has broad development and application space in clinical disease prediction, early intervention and diagnosis and treatment, and has become a research focus in recent years. However, circular RNA is relatively rare in non-tumor obstetrics and gynecology diseases. Therefore, circular RNA is briefly introduced and its research progress in non-tumor related diseases in human reproduction and pregnancy is briefly summary in this article.

Key words： Circular RNA Reproduction Pregnancy Recurrent spontaneous abortion Prenatal diagnosis

基金资助:江苏省扬州市科技计划项目（YZ2017069）

引用本文:

赵一燕；鞠捷；孔祥 . 环状RNA在人类生殖妊娠方面的研究进展[J]. 中国当代医药, 2020, 27(19): 22-26.
ZHAO Yi-yan；JU Jie；KONG Xiang. Research progress of circular RNA in the area of reproduction and pregnancy. 中国当代医药, 2020, 27(19): 22-26.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2020/V27/I19/22

[1]	Sanger HL，Klotz G，Riesner D，et al.Viroids are singlestranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures[J].Proc Natl Acad Sci U S A，1976，73（11）：3852-3856.
[2]	Arnberg AC，Van Ommen GJ，Grivell LA，et al.Some yeast mitochondrial RNAs are circular[J].Cell，1980，19（2）：313-319.
[3]	Cocquerelle C，Mascrez B，Hetuin D，et al.Mis-splicing yields circular RNA molecules[J].FASEB J，1993，7（1）：155-160.
[4]	Hsu MT，Coca-Prados M.Electron microscopic evidence for the circular form of RN A in the cytoplasm of eukaryotic cells[J].Nature，1979，280（5720）：339-340.
[5]	Liu L，Wang J，Khanabdali R，et al.Circular RNAs：Isolation，characterization and their potential role in diseases[J].RNA Biology，2017，14（12）：1715-1721.
[6]	Lyu D，Huang S.The emerging role and clinical implication of human exonic circular RNA[J].RNA Biol，2017，14（8）：1000-1006.
[7]	Jeck WR，Sorrentino JA，Wang K，et al.Circular RNAs are abundant，conserved，and associated with ALU repeats[J].RNA，2013，19（2）：141-157.
[8]	Conn SJ，Pillman KA，Toubia J，et al.The RNA binding protein quaking regulates formation of circRNAs[J].Cell，2015，160（6）：1125-1134.
[9]	Ashwal-Fluss R，Meyer M，Pamudurti NR，et al.circRNA biogenesis competes with pre-mRNA splicing[J].Mol Cell，2014，56（1）：55-66.
[10]	Rybak-Wolf A，Stottmeister C，Glazar P，et al.Circular RNAs in the mammalian brain are highly abundant，conserved，and dynamically expressed[J].Mol Cell，2015，58（5）：870-885.
[11]	Dang Y，Yan L，Hu B，et al.Tracing the expression of circular RNAs in human pre-implantation embryos[J].Genome Biol，2016，17（1）：130
[12]	Qu S，Yang X，Li X，et al.Circular RNA：A new star of noncoding RNAs[J].Cancer Lett，2015，365（2）：141-148.
[13]	Ebert MS，Neilson JR，Sharp PA.MicroRNA sponges：competitive inhibitors of small RNAs in mammalian cells[J].Nat Methods，2007，4（9）：721-726.
[14]	Yao Q，Chen Y，Zhou X.The roles of microRNAs in epigenetic regulation[J].Curr Opin Chem Biol，2019，51（1）：11-17.
[15]	Du WW，Yang W，Liu E，et al.Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2[J].Nucleic Acids Res，2016，44（6）：2846-2858.
[16]	Abe N，Matsumoto K，Nishihara M，et al.Rolling circle translation of circular RNA in living human cells[J].Sci Rep，2015，5：16 435.
[20]	Shen L，Zhang Y，Zhou W，et al.Circular RNA expression in ovarian endometriosis[J].Epigenomics，2018，10（5）：559-572.
[25]	Qian Z，Liu H，Li M，et al.Potential diagnostic power of blood circular RNA expression in active pulmonary tuberculosis[J].E Bio Med，2018，27：18-26.
[17]	Che Q，Liu M，Xu J，et al.Characterization of circular RNA expression profiles in cumulus cells from patients with polycystic ovary syndrome[J].Fertil Steril，2019，111（6）：1243-1251.e1.
[18]	Ma Z，Zhao H，Zhang Y，et al.Novel circular RNA expression in the cumulus cells of patients with polycystic ovary syndrome[J].Arch Gynecol Obstet，2019，299（6）：1715-1725.
[19]	Zhang C，Liu J，Lai M，et al.Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome[J].Arch Gynecol Obstet，2019，300（2）：431-440.
[21]	Wang D，Luo Y，Wang G，et al.Circular RNA expression profiles and bioinformatics analysis in ovarian endometriosis[J].Mol Genet Genomic Med，2019，7（7）：e00756.
[22]	Zhang M，Wang S，Tang L，et al.Downregulated circular RNA hsa_circ_0067301 regulates epithelial-mesenchymal transition in endometriosis via the miR-141/Notch signaling pathway[J].Biochem Biophys Res Commun，2019，514（1）：71-77.
[23]	Liu L，Li L，Ma X，et al.Altered circular RNA expression in patients with repeated implantation failure[J].Cell Physiol Biochem，2017，44（1）：303-313.
[24]	Zhuang ZG，Zhang JA，Luo HL，et al.The circular RNA of peripheral blood mononuclear cells：Hsa_circ_0005836 as a new diagnostic biomarker and therapeutic target of active pulmonary tuberculosis[J].Mol Immunol，2017，90：264-272.
[26]	Huang ZK，Yao FY，Xu JQ，et al.Microarray expression profile of circular RNAs in peripheral blood mononuclear cells from active tuberculosis patients[J].Cell Physiol Bioch em，2018，45（3）：1230-1240.
[27]	Dong WW，Li HM，Qing XR，et al.Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma[J].Sci Rep，2016，6：39 080.
[28]	李颖.人精子环状RNA 表达特征及其与弱精症的相关性研究[D].郑州:郑州大学，2019.
[29]	张辰望.DAZ 家族基因生殖特异表达的机制及保守性研究[D].南京：南京医科大学，2015.
[30]	Practice Committee of the American Society for Reproductive M.Evaluation and treatment of recurrent pregnancy loss：a committee opinion[J].Fertil Steril，2012，98（5）：1103-1111.
[31]	Qian Y，Wang X，Ruan H，et al.Circular RNAs expressed in chorionic villi are probably involved in the occurrence of recurrent spontaneous abortion[J].Biomed Pharmacotherapy，2017，88：1154-1162.
[32]	Lopez-Alarcon M，Montalvo-Velarde I，Vital-Reyes VS，et al.Serial determinations of asymmetric dimethylarginine and homocysteine during pregnancy to predict pre-eclampsia：a longitudinal study[J].BJOG，2015，122（12）：1586-1592.
[33]	Qian Y，Lu Y，Rui C，et al.Potential Significance of Circular RNA in Human Placental Tissue for Patients with Preeclampsia[J].Cell Physiol Biochem，2016，39（4）：1380-1390.
[34]	Zhang YG，Yang HL，Long Y，et al.Circular RNA in blood corpuscles combined with plasma protein factor for early prediction of pre-eclampsia[J].BJOG，2016，123（13）：2113-2118.
[35]	Deng N，Lei D，Huang J，et al.Circular RNA expression profiling identifies hsa_circ_0011460 as a novel molecule in severe preeclampsia[J].Pregnancy Hypertens，2019，17：216-225.
[36]	Prefumo F.Circular RNA and pre-eclampsia：on the long road from the laboratory to the bedside[J].BJOG，2016，123（13）：2119.
[37]	Gao C，Sun X，Lu L，et al.Prevalence of gestational diabetes mellitus in mainland China：A systematic review and meta-analysis[J].J Diabetes Investig，2019，10（1）：154-162.
[38]	陈瑞华，杨红玲，陈荣，等.妊娠期糖尿病孕妇血中环状核糖核酸表达谱的巢式病例对照研究[J].中华围产医学杂志，2019，22（4）：255-260.
[39]	Yan L，Feng J，Cheng F，et al.Circular RNA expression profiles in placental villi from women with gestational diabetes mellitus[J].Biochem Biophys Res Commun，2018，498（4）：743-750.
[40]	王辉辉.环状RNA 在妊娠期糖尿病患者胎盘表达的研究[D].南京：南京医科大学，2018.
[41]	Xu T，Wu J，Han P，et al.Circular RNA expression profiles and features in human tissues：a study using RNA-seq data[J].BMC Genomics，2017，18（Suppl 6）：680.
[42]	Szabo L，Morey R，Palpant NJ，et al.Statistically based splicing detection reveals neural enrichment and tissuespecific induction of circular RNA during human fetal development[J].Genome Biol，2015，16：126.
[43]	林南新，汤冬娥，龚蔚蔚，等.基于RNA-seq 技术对13-三体综合征脐带血差异性表达环状RNA 研究[J].中国产前诊断杂志（电子版），2019，11（1）：6-10.
[44]	林南新.13-三体综合征circRNA 表达谱分析及其相关ceRNA 网络的构建[D].桂林：广西师范大学，2019.
[45]	邹耀霜，晏强，眭维国，等.环状RNA 在孕妇18-三体综合征的鉴定与分析[J].中国产前诊断杂志（电子版），2018，10（1）：15-19.
[46]	常燕.唐氏综合征母体胎源性CircRNA 差异性表达谱及功能分析[D].桂林：广西师范大学，2017.