Abstract：Objective To explore the application effect of 3%hypertonic saline and 20%Mannitol in children with intracranial hypertension.Methods The clinical data of 44 children with intracranial hypertension admitted to our hospital from July 2016 to December 2018 were collected and divided into observation group and control group according to the order of admission,22 cases in each group.The observation group was treated with 3%hypertonic saline,while the control group was treated with 20%Mannitol,the rest of the treatment depended on the specific situation.The effect of reducing intracranial pressure,the final effect,serum sodium,osmotic pressure and hospitalization time were compared between the two groups.Results There was no significant difference in intracranial pressure between the two groups before treatment(P>0.05).The intracranial pressure level of the two groups after treatment were lower than those before treatment,the differences were statistically significant(P<0.05).The level of intracranial pressure in the observation group after treatment was lower than that in the control group,the difference was statistically significant(P<0.05).The total effective rate of the observation group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).There was no significant difference in serum sodium and osmotic pressure between the two groups before treatment(P>0.05).After 3 days of treatment,the level of serum sodium in the control group was lower than that before treatment,and the level of plasma osmotic pressure was higher than that before treatment,the differences were statistically significant(P<0.05).The levels of serum sodium and plasma osmotic pressure in the observation group were higher than those before treatment and in the control group,the differences were statistically significant(P<0.05).There was no significant difference in hospitalization time between the two groups(P>0.05).Conclusion 3%hypertonic saline is superior to 20%mannitol in lowering intracranial pressure in children with intracranial hypertension,and does not reduce serum sodium concentration and osmotic pressure,which is worthy of clinical application.
戴本启； 林雪； 张志梅； 吴敏； 林思敏. 3%高渗盐水在儿童颅内高压中的应用效果[J]. 中国当代医药, 2019, 26(17): 82-85.
DAI Ben-qi； LIN Xue； ZHANG Zhi-mei； WU Min； LIN Si-min. Application effect of 3%hypertonic saline in children with intracranial hypertension. 中国当代医药, 2019, 26(17): 82-85.
Weed LH，McKibben PS.Presure ohanges in the cerebrosp inalfluid following intravenous injection of solutions of various concenctrations[J].Am J Physiol，1919，48(9)：512-530．
Alnemari AM，Krafcik BM，Mansour TR，et al.A Comparison of pharmacologic therapeutic agents used for the reduction of intracranial pressure after traumatic brain injury[J].World Neurosurg，2017，106（4）：509-528.
Kamel H，Navi BB，Nakagawa K，et al.Hypertonic saline ver-SUS mannitol for the treatment of elevated intracranial pressure：a meta—analysis of randomized clinical trials[J].Crit Care Med，2011，39（3）：554-559．
Bratton SL，Chestnut RM，Ghaja RJ，et al.Guidelines for the management of severe traumatic brain injuryⅡHyperosmolar therapy[J].Neurotrauma，2007，24（1）：S14-S20.
京公网安备 11010502046607号