Abstract:Objective To approach curative effect and security analyzing of elderly late stage gastric cancer by Capecitabine combined with Thymic Peptide.Methods Sixty-four elderly patients with advanced gastric cancer admitted to our hospital from February 2014 to February 2016 were divided into treatment group A (Capecitabine treatment group)and treatment group B (Capecitabine combined with Thymic Deptide treatment group),with 32 cases in each group.The short-term efficacy,long-term efficacy and adverse reactions were compared between the two groups.Results The total remission rate of elderly patients with advanced gastric cancer in group B was higher than that in group A,while the progression time and survival time of elderly patients with advanced gastric cancer in group B were shorter than those in group A(P<0.05),there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The elderly late stage gastric cancer patients by Capecitabine combined with Thymic Peptide treatment,short-term curative effect and long-term curative effect are good,security is high,it is worth to be used.
李旭丹;陈海龙. 卡培他滨联合胸腺肽在老年晚期胃癌的疗效及安全性分析[J]. 中国当代医药, 2018, 25(8): 46-48.
LI Xu-dan;CHEN Hai-long. The curative effect and security analyzing of elderly late stage gastric cancer by Capecitabine combined with Thymic peptide. 中国当代医药, 2018, 25(8): 46-48.
Coccolini F,Montori G,Ceresoli M,et al.Advanced gastric cancer:What we know and what we still have to learn[J].World J Gastroenterol,2016,22(3):1139-1159.
Cui Y,Li Q,Yu Y,et al.Combination of low-dose Docetaxel and standard-dose S-1 for the treatment of advanced gastric cancer:efficacy,toxicity,and potential predictive factor[J].Cancer Chemother Pharmacol,2013,71(1):145-152.
Petrioli R,Francini E,Roviello F,et al.Treatment of advanced oesophagogastric cancer with FOLFOX-4 regimen followed by Leucovorin/Bolus and continuous infusion 5-FU as maintenancechemotherapyinpatientsaged≥75yearswith impaired performance status[J].J Geriatr Oncol,2015,6(5):380-386.
Chen J,Shen W,Xia J,et al.Effect of S-1 maintenance chemotherapy following DCF regimen in patients with advancedgastric cancer[J].J Sorthern Med Univ,2014,34(7):1057-1060.
Qiu MZ,Wei XL,Zhang DS,et al.Efficacy and safety of capecitabine as maintenance treatment after first-line chemotherapy using and capecitabine in advanced gastric adenocarcinoma patients:a prospective observation[J].Tumour Biol,2014,35(5):4369-4375.
[15]
汝童,刘铁夫.胃癌诊断的研究进展[J].医学综述,2014,20(24):4475-4477.
[16]
Gong J,Hu B,Zhang X,et al.The multicenter,phase Ⅱprospective study of paclitaxel plus Capecitabine as firstline chemotherapy in advanced gastric carcinoma[J].Oncologist,2014,19(2):173-174.