Abstract：Objective To study and analyze the clinical effects and safety of Compound Polymyxin B Ointment combined with Adapalene Gel in treatment of acne vulgaris.Methods A total of 128 cases of patients with acne vulgaris who treated in our hospital from January 2016 to August 2017 were selected as subjects,and were divided into the observation group and the control group according to the random number grouping method,with 64 cases in each group.The patients in the control group were treated with only Compound Polymyxin B Ointment,while the patients in the observation group were treated with Compound Polymyxin B Ointment combined with Adapalene Gel.The effects,the occurrence of adverse reactions and the skin lesions counts after treatment of patients between the two groups were observed.Results The total effective rate of the patients in the observation group was 98.44%,which was significantly higher than that in the control group of 87.50%,the difference was statistically significant(P<0.05).The total incidence of adverse reaction in the observation group was 9.38%,which was significantly lower than that in the control group of 21.88%,the difference was statistically significant(P<0.05).The skin lesions(papule,comedo,pimple)counts of the patients in the observation group were less than those of the control group,and the differences were statistically significant(P<0.05).Conclusion The effect of Compound Polymyxin B Ointment combined with Adapalene Gel in treatment of acne vulgaris are significant,which greatly reduce the patients′skin lesion counts,promotes the recovery of the patient,and it have high safety,thus it is worth promoting and using in clinical.
刘宇倩;赖永珲;文立章;杨帆;潘鹏;莫衍石;罗斌. 复方多粘菌素B软膏联合阿达帕林凝胶治疗寻常型痤疮的效果和安全性分析[J]. 中国当代医药, 2018, 25(15): 88-90.
LIU Yu-qian;LAI Yong-hui; WEN Li-zhang;YANG Fan;PAN Peng;MO Yan-shi;LUO Bin. Analysis of clinical effect and safety of Compound Polymyxin B Ointment combined with Adapalene Gel in treatment of acne vulgaris. 中国当代医药, 2018, 25(15): 88-90.
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