Abstract：Objective To investigate effect of Alteplase thrombolysis in the treatment of ST-segment elevation acute myocardial infarction.Methods 152 patients with ST-segment elevation acute myocardial infarction treated in our hospital from October 2012 to October 2015 were selected and divided into control group and observation group by random number table method,76 cases in each group.Patients in the control group were treated with Urokinase,while patients in the observation group treated with Alteplase.Electrocardiogram was detected before and after treatment.Cardiovascular reperfusion was analyzed at different time points.Clinical efficacy and adverse reactions were compared between two groups.Results Compared with before treatment,Q wave time,Q wave/R wave,ST segment deviation after treatment was decreased in two groups(P＜0.01);Q wave time[(0.042±0.009)d],Q wave/R wave(0.31±0.06),ST segment deviation[(3.20± 0.57)mV]in the observation group was lower than that in the control group[(0.051±0.010)d,0.36±0.05,(4.35±0.61)mV] (P＜0.01).Compared at same time points in the group,cardiovascular reperfusion rate of patients with onset time≤6 h was higher than that of patients with onset time＞6 h(P＜0.05);compared at same time points between two groups,cardiovascular reperfusion rate in the observation group was higher than that in the control group(P＜0.05).Total effective rate in the observation group was higher than that in the control group(97.4%vs.82.9%)(P＜0.01).Incidence of adverse reactions in the observation group was lower than that in the control group(2.6%vs.13.2%),and the difference was statistically significant(P＜0.05).Conclusion Alteplase thrombolysis has significant effect in the treatment of ST-segment elevation acute myocardial infarction,which has high safety,which is worthy of clinical application.
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