Correlation study between coagulation function and arterial blood gas indexes in acute exacerbation of chronic obstructive pulmonary disease
JIANG Ling-zhi1 XU Dan-yuan2 YANG Zhi-xiong2
1.Intensive Care Unit,the Fourth Affiliated Hospital of Guangzhou Medical University,Guangdong Province,Guangzhou 511447,China;
2.Department of Respiratory Medicine,the Fourth Affiliated Hospital of Guangzhou Medical University,Guangdong Province,Guangzhou 511447,China
Abstract：ObjectiveTo explore the correlation between coagulation function and arterial blood gas indexes in acute exacerbation of chronic obstructive pulmonary disease.Methods56 patients with acute exacerbation of chronic obstruc tive pulmonary disease admitted to our hospital from June 2013 to August 2015 were selected as group A,after treatment were selected as group B,on the other hand,56 healthy persons for physical examination in our hospital were selected as group C.The level of fibrinogen(Fbg),D-two dimer(D-D),prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),oxygen partial pressure(PaO2),partial pressure of carbon dioxide(PaCO2)of all the research object were determined,the correlation between blood coagulation function index and arterial blood gas indexes was analyzed.ResultsThere was no significant difference in the level of PT,APTT and TT between the three groups(P＞0.05);the levels of D-D,Fbg,PaCO2in group A was higher than that in group B and group C,the difference was statistically significant(P＜0.05),and the PaO2level was lower than that of B and C group,the difference was statistically significant(P＜0.05).There are negative correlation between D-D and PaO2,the difference was statistically significant(r=-0.232,P＜0.05);D-D was positively correlated with PaCO2,the difference was statistically significant(r=0.284,P＜0.05);Fbg was positively correlated with PaCO2,the difference was statistically significant(r=0.437,P＜0.05);Fbg was negatively correlated with PaO2,with significant difference(r=-0.465,P＜0.05).ConclusionThere is a high coagulation state in acute exacerbation of chronic obstructive pulmonary disease,and the monitoring of D-D and Fbg indexes can provide a certain data base for the improvement of prognosis.
蒋凌志;许丹媛;杨志雄. 慢性阻塞性肺疾病急性加重期凝血功能与血气指标的相关性研究[J]. 中国当代医药, 2017, 24(18): 114-117.
JIANG Ling-zhi;XU Dan-yuan;YANG Zhi-xiong. Correlation study between coagulation function and arterial blood gas indexes in acute exacerbation of chronic obstructive pulmonary disease. 中国当代医药, 2017, 24(18): 114-117.
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