摘要目的探讨吸人型糖皮质激素治疗急性哮喘发作患儿的效果。方法选取本院2014年3月~2015年3月收治的92例急性哮喘发作患儿作为研究对象,随机分为治疗组和对照组,各46例。两组均吸人支气管舒张剂,在此基础上,治疗组行氧动雾化吸人法吸人布地奈德,对照组行氧动雾化吸人法吸人生理盐水。比较两组治疗前及治疗后0、1、2 h的心率、肺通气功能、呼吸频率、临床症状评分和血氧饱和度情况。结果两组治疗后0、1、2 h 的FEV1、FEV1%、呼吸频率、临床症状评分、血氧饱和度水平与治疗前比较,差异有统计学意义(P<0.05)。治疗组治疗后2 h的临床症状评分显著低于对照组,差异有统计学意义(P<0.05)。治疗组治疗后各时间段的缓解情况、全身使用糖皮质激素和住院情况显著优于对照组,差异有统计学意义(P<0.05)。结论支气管舒张剂与糖皮质激素可起到协同作用,不仅能够缓解急性哮喘发作患儿的病情,还可以促进肺功能恢复正常,降低住院率及全身糖皮质激素使用率。
Abstract:Objective To exp1ore the effect of inha1ed g1ucocorticoid in the treatment of chi1dren patient with acute asthma.Methods 92 asthma chi1dren patient from March 2014 to March 2015 in our hospita1 were se1ected and random1y divided into the treatment group and the contro1 group,46 cases in each group.A11 patients were treated with inha1ation bronchi re1axation.On the basis of that,the treatment group was treated with oxygen atomizationatomized inha1ation for inha1ation of budesonide,the contro1 group was given oxygen atomization atomized inha1ation for inha1ation of norma1 sa1ine.Heart rate,pu1monary venti1ation function,respiratory rate,c1inica1 symptom score and saturation of b1ood oxygen before treatment and 0,1,2 h after treatment in the two group was compared respective1y.Results There was significant difference in the 1eve1 of FEV1,FEV1%,respiratory rate,c1inica1 symptom score and b1ood oxygen saturation between 0,1,2 h after treatment and before treatment(P<0.05).The score of c1inica1 symptom after treatment for 2 h in the treatment group was 1ower than that in the contro1 group,with significant difference(P<0.05).Remission situation of a11 stage,hospita1ization situation and using rate of systemic corticosteroid in the treatment group was better than that in the contro1 group,with significant difference(P<0.05).Conclusion Bronchi re1axation and g1ucocorticoid has synergistic effect,which not on1y can re1ieve the disease of acute asthma chi1dren patient,but a1so can promote 1ung function recovery,reduce hospita1ization rate and use rate of systemic g1ucocorticoid.
区贵英. 吸入型糖皮质激素治疗急性哮喘发作患儿的效果分析[J]. 中国当代医药, 2016, 23(5): 134-136.
OU Gui-ying. Effect analysis of inhaled glucocorticoid in the treatment of children Patient with acute asthma. 中国当代医药, 2016, 23(5): 134-136.