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2020 Vol. 27, No. 32
Published: 2020-11-18
4
Inhibitory effect of Liuwei Dihuang Pills combined with dendritic cells on gastric cancer cells
SUN Xiao-yan1 YU Bo1 LIN Li-juan2▲
Guide::
Objective
To study the inhibitory effect of Liuwei Dihuang Pills combined with dendritic cells on gastric cancer cells.
Methods
Gastric cancer antigen was prepared by repeated freeze-thaw method to sensitize rat bone marrow-derived dendritic cells.Altogether 24 SD rats for in vitro experiments were randomly divided into four groups,namely blank control group (group A),dendritic cells group (group B),Liuwei Dihuang Pills group (group C),and drugcontaining dendritic cells group (group D),with 6 rats in each group.Twenty-four NOD/SCID rats were selected for in vivo experiments (randomly divided into group a,b,c,and d,with 6 rats in each group).The inhibitory effect of each group on gastric cancer cells was detected respectively by drawing cell growth curve,plate cloning experiments,and in vivo tumor formation experiment.
Results
The growth curve of tumor cells showed that with the extension of time,group D had more obvious inhibitory effect on gastric cancer cells,with statistically significant difference (P<0.05).According to the results of plate cloning experiment,the statistically significant difference was found in the cell clone formation rate between group A and group D (P<0.05).In vivo tumor formation experiment results showed that the tumor tissue was obtained after multiple intragastric administration and injection of dendritic cells,the tumor volume of group D was smaller than that of group A,with statistically significant difference (P<0.05).
Conclusion
Combination of Liuwei Dihuang Pills and dendritic cells has killing effect on gastric cancer cells,which is better than that of single Liuwei Dihuang Pills or dendritic cells alone.
2020 Vol. 27 (32): 4-8 [
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Retrospective analysis of colposcopy biopsy results in 871 cases of human papillomavirus 16/18 positive patients
YU Gui-yuan1 CHEN Min-jie2 MIN Qing-hua3 HE Shu-fang3▲
Guide::
Objective
To retrospectively analyze the results of ThinPrep cytologic test (TCT) and colposcopy biopsy of human papillomavirus (HPV) 16/18 positive patients,and to explore the value of using HPV16/18 partial typing in the early diagnosis of cervical lesions.
Methods
Altogether 871 cases of HPV16/18 positive patients who were referred for colposcopy biopsy in the Department of Obstetrics and Gynecology,the First Affiliated Hospital of Nanchang University from January 2016 to January 2018 were collected,and their age,TCT,HPV and the pathological results were collected for statistical analysis.
Results
Of all the 871 patients included in this study,469 cases (53.8%) were cervical inflammation,111 cases (12.7%) were cervical intraepithelial neoplasia 1 (CIN1),84 cases (9.6%) were CIN2,124 cases(14.2%) were CIN3,and 83 cases (9.5%) were cervical cancer.The HPV16/18 positive patients were subgrouped into 21-30,>30-40,>40-50,and >50 years old,and the proportions of CIN2+lesions were 19.1% (31/162) and 28.4% (64/225),39.1% (109/279),42.4% (87/205),respectively.Among the HPV16/18 positive and menopausal patients,the detection rate of CIN2+lesions was higher than that of non-menopausal patients (40.4% vs.30.7%),and the difference was statistically significant (χ
2
=7.31,P<0.01).
Conclusion
The detection rate of CIN2+lesions in HPV16/18 positive patients is about 33.4%,and with the increase of age,the detection rate of CIN2+tends to increase gradually.The immediate transfer of patients to colposcopy whose HPV16/18 shows positive is very helpful to the early detection of cervical lesions.
2020 Vol. 27 (32): 9-12 [
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13
Effect of ultrasound-guided posterior transversus abdominis plane block on analgesia after cesarean section
CHEN Mao-fang ZHANG Chun-yuan LUO Guo-zhan ZENG Wei TAN Mei-yun WU Yan-wen MA Jian
Guide::
Objective
To study the effect of ultrasound-guided posterior transversus abdominis plane block (TAPB) on analgesia after cesarean section.
Methods
From July to October 2019,60 parturients undergoing cesarean section under the combined spinal and epidural anesthesia in Boai Hospital of Zhongshan were selected as the research objects and they were divided into the experimental group (30 cases) and the control group (30 cases) according to the random number table method.After the operation,both groups received patient-controlled intravenous analgesia (PCIA),and the experimental group received ultrasound-guided posterior TAPB after the operation.The rest and dynamic visual analogue scale (VAS) scores at 4,8,12,24,and 48 hours after surgery,the dosage of Sufentanil,the frequency of patientcontrolled analgesia compressions,the occurrence of adverse reactions,and satisfaction score were compared between the two groups,and the occurrence of complications related to TAPB operation in the experimental group was observed.
Results
The rest and dynamic VAS scores of the experimental group at 8,12,and 24 hours after surgery were lower than those of the control group,at 0-23 hours after surgery,the dosage of Sufentanil and the frequency of self-controlled analgesia compressions in the experimental group were less than those in the control group,the differences were statistically significant (P<0.05).The dosage of Sufentanil in the experimental group was less than that in the control group at 24 to 48 hours after surgery,and the satisfaction score was higher than that in the control group,the differences were statistically significant (P<0.05).There was no statistically significant difference in the incidence of adverse reactions (nausea and vomiting,dizziness,skin itching,respiratory depression and urinary retention) between the two groups (P>0.05).No complications related to TAPB operation occurred in the experimental group.
Conclusion
Ultrasound-guided posterior TAPB can effectively reduce the postoperative pain of parturients after cesarean section,with longer duration of analgesia (24 hours),higher safety and satisfaction.
2020 Vol. 27 (32): 13-16 [
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17
Research progress of inflammation,fibrosis and cytokines in primary frozen shoulder
LI Qing-hua1,3 WANG Kai1 CUI Tong-qing2 CHEN Gen3 XIE Qiang3 DING Jie3▲
Guide::
Shoulder pain with limited range of motion is main feature of frozen shoulder,it′s one of common and frequently-occurring diseases of middle-aged and elderly people in today′s society.In recent years,the disability of frozen shoulder imposed a heavy burden on the national and social medical undertakings,which seriously threatens human health.Although there are relevant research literatures describing the physiological and pathological mechanism of frozen shoulder,however,there still have large differences in the specific factors and the explanation of the cause of the disease related to frozen shoulder.Affect the patients′ lives are shoulder pain and limited range of motion.Recent studies found that inflammation,fibrosis and cytokines are closely related to pain and limited range of motion in frozen shoulder patients.Therefore,this study aims to explore the relationship between inflammation,fibrosis and cytokines with frozen shoulder to clarify the causes and provide a theoretical basis for reducing the pain and increasing the range of motion of frozen shoulder patients.This article studies the relationship between inflammation,cytokines,fibrosis and frozen shoulders.It′s found that inflammation and cytokine factors are closely related to patients′ shoulder pain,and fibrosis is closely related to patients′ decreased range of motion.
2020 Vol. 27 (32): 17-20 [
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18
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25
Theoretical discussion about the therapeutic method of strengthening healthy qi in treating Sjogren′s syndrome
HU Jian-guo ZHAO Min JIANG Gui-xiu LI Qian-yu
Guide::
Sjogren′s syndrome (SS) is a systemic disease in which the exocrine glands are the main affected tissue.Dry mouth,dry eyes,fatigue and other symptoms in SS patients can affect their quality of life.Occurrence of SS is related to the organism′s immune imbalance.Therapeutic methods of strengthening healthy qi in traditional Chinese medicine(TCM) can just intervene on the organism′s immune imbalance.This article summarizes the application of the therapeutic method of strengthening healthy qi in the treatment of SS in recent years.Therapeutic methods of strengthening healthy qi for the treatment of SS include therapeutic method of invigorating qi and nourishing yin,therapeutic method of nourishing yin fluid,therapeutic method of regulating zang-organs and fu-organs,and therapeutic method of balancing yin and yang,etc.Therapeutic method of strengthening healthy qi has achieved good results in the treatment of SS and improved the quality of life of SS patients.It deserves further clinical summary and improvement.Meanwhile,it shall further strengthen the standardized research of TCM in the treatment of SS,in order to conclude more effective prescriptions for the treatment of SS.
2020 Vol. 27 (32): 25-31 [
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32
Effect comparison of minimally invasive single condylar replacement and total knee arthroplasty in the treatment of single compartment osteoarthritis of knee joint
XIE Jing-bo XIAO Yi-bing XIONG Jun-wei ZHENG Tao YAN Qiu-yuan
Guide::
Objective
To compare the efficacy of minimally invasive single condylar replacement and total knee arthroplasty in the treatment of single compartment osteoarthritis of knee joint.
Methods
Knee osteoarthritis patients admitted to Fengcheng People′s Hospital from May 2018 to December 2019 were selected for retrospective analysis.A total of 30 patients with single-compartment knee osteoarthritis(30 knee joints)who underwent minimally invasive monocondyle replacement surgery as the observation group,and 30 patients with knee osteoarthritis (30 knee joints) who received total knee arthroplasty as the control group.The relevant clinical data of the two groups before and after the operation were sorted,and the postoperative symptom relief,the HSS score of knee joint function,the subjective satisfaction of the patients,the blood loss during the operation,the operation time,the length of stay,the treatment cost of the two groups were compared.
Results
There was no significant difference in the HSS scores of knee joint function between the two groups before treatment (P＞0.05);after treatment,the HSS scores of knee joint function in both groups were higher than those before treatment,and the observation group was higher than the control group,the differences were statistically significant (P＜0.05).The postoperative symptom relief rate of the observation group was higher than that of the control group,the difference was statistically significant (P＜0.05).The subjective satisfaction of the observation group was higher than that of the control group,the blood loss during operation was less than that of the control group,the operation time and hospital stay were shorter than those of the control group,and the treatment cost was lower than that of the control group,the differences were statistically significant (P＜0.05).
Conclusion
Minimally invasive single condyle replacement for single-compartment knee osteoarthritis has less trauma,less bleeding,and shorter operation time.Postoperative symptoms have improved significantly,no obvious complications occurred,and hospitalization costs are lower than total knee replacement surgery.
2020 Vol. 27 (32): 32-35 [
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36
Clinical effect of high-frequency electric resection under electronic bronchoscope combined with freezing and local administration on granulation bronchial tuberculosis
ZHANG Xue-yu WAN Li ZHONG Cheng XIAO Xiao-hao LIU Lan-zhen
Guide::
Objective
To analyze the clinical effect of high-frequency electrocision combined with cryotherapy and local administration in the treatment of granuloproliferative bronchial tuberculosis under electronic bronchoscopy.
Methods
A total of 40 patients with granulomatous bronchial tuberculosis admitted to Jiangxi Chest Hospital from January 2018 to December 2019 were selected as the research objects,they were divided into the control group (20 cases) and the observation group (20 cases) according to the lottery method.The patients in the control group were treated with cryotherapy and local administration,and the patients in the observation group were treated with electronic bronchoscopy under high frequency electrocision combined with cryotherapy and local administration.The total treatment efficiency,tuberculosis lesion absorption rate,number of treatments and complications were compared between the two groups.
Results
The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05);the absorption rate of tuberculosis lesions in the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05);the average number of treatment of the observation group was less than that of the control group,and the difference was statistically significant(P＜0.05);the incidence of complications between the two groups was not statistically significant (P＞0.05).
Conclusion
Electronic bronchoscopy combined with high-frequency electroresection combined with cryotherapy and local administration in the treatment of granulomatous proliferative bronchial tuberculosis has a significant clinical effect and high safety.It is recommended to be further promoted clinically.
2020 Vol. 27 (32): 36-39 [
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Effect observation of 75% alcohol+Haijinsha fresh grass pounding mud for external use combined with Acyclovir in the treatment of herpes zoster neuralgia
LI Shi-ping CHEN Ye-fei DENG Liang-yuan YAN Jian-yong HU Yao LI Wei
Guide::
Objective
To explore the effect of 75% alcohol+Haijinsha fresh grass pounding mud for external use combined with Acyclovir in the treatment of herpes zoster neuralgia.
Methods
The 30 patients with herpes zoster neuralgia who refused to be admitted to Lianhua County People′s Hospital from December 2016 to April 2020 were selected as the control group,and the 30 patients with herpes zoster neuralgia who received hospitalization during the same period were selected as the observation group.The control group received conventional treatment,namely oral and external acyclovir.On this basis,the observation group combined topical 75% alcohol+Haijinsha fresh grass pounding mud for treatment.The clinical efficacy,symptom relief time,pain degree (visual analogue scale [VAS]) before and after treatment and the changes of inflammatory factors were compared between the two groups of patients,which included interleukin 6(IL-6),serum high-sensitivity C-reactive protein (hs-CRP),necrosis factor-α(TNF-α).
Results
The total effective rate of treatment in the observation group was higher than that in the control group,the difference was statistically significant (P＜0.05).The redness,swelling,scab,and neuralgia relief time of the observation group were all higher than those in the control group,the differences were statistically significant (P＜0.05).There was no statistically significant difference between the VAS scores of the two groups before treatment (P＞0.05);the VAS scores of the two groups after treatment were lower than before treatment,and the VAS score of the observation group was lower than in the control group,the difference was statistically significant (P＜0.05).The hs-CRP,IL-6 and TNF-α before treatment in the two groups were not statistically significant (P＞0.05);the hs-CRP,IL-6 and TNF-α after treatment in both groups were lower than before treatment,and the levels in the observation group were lower than those of the control group,the differences were statistically significant (P＜0.05).
Conclusion
For the treatment of herpes zoster neuralgia,using 75%alcohol+Haijinsha fresh grass pounding mud external application combined with Acyclovir treatment has a significant effect,which can effectively shorten the course of the disease,relieve pain,inhibit the release of serum inflammatory factors,and promote the reduction or disappearance of symptoms.It is worth studying in the future.
2020 Vol. 27 (32): 40-42 [
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47
Application effect of indwelling needle film in fixation of ostomy bag
DENG Zhen-zhen HU Hui-ting CHEN Yan-jun
Guide::
Objective
To explore the application effect of indwelling needle patch in the fixation of ostomy bags.
Methods
A total of 24 patients who were treated in Affiliated Hospital of Jinggangshan University from June to October 2019 were selected as the research objects.They were divided into observation group and control group by scientific random sampling,12 cases in each group.The control group was pasted using the conventional method of ostomy,and the observation group was fixed with an indwelling needle film on the edge of the ostomy after the ostomy fixed.Ostomy bag usage time,dressing costs,consumables and ostomy skin damage were compared between the two groups.
Results
The number of ostomy bags used in the observation group was longer than that of the control group (P<0.05).The dressing fee，the number of dressing changes and the total cost of the observation group were less than those of the control group (P<0.05),while the material fee was not significantly different from that of the control group (P＞0.05).There were no ostomy skin damage in the observation group.In the control group,1 patient (8.00%) had skin damage and 2 patients (17.00%) had dermatitis.
Conclusion
The use of indwelling needle film to fix the edge of the ostomy bag can prolong the use time of the ostomy bag,reduce the cost of dressing change,and avoid causing skin damage to the ostomy.It is worthy of clinical popularization and application.
2020 Vol. 27 (32): 47-49 [
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50
Clinical effect of Wuzhi Dripping Pills combined with Entecavir in treatment of chronic hepatitis B
HU Jiang-ling XU Fei JIANG Man-lei LUO Jia-yu
Guide::
Objective
To observe the clinical effect of Wuzhi Dripping Pills combined with Entecavir in treatment of chronic hepatitis B (CHB).
Methods
A total of 80 patients with CHB who admitted to Ganzhou Fifth People′s Hospital from December 2015 to December 2019 were selected and divided into two groups according to random number table method,40 cases in each group.The control group was given Entecavir and Interferon,and research group added Wuzhi Dripping Pills.The total effective rate,TCM syndrome score,liver function （alanine transaminase [ALT],aspartic transaminase [AST],γ-glutamyl transpeptidase [GGT]）,and adverse reactions were compared between two groups.
Results
The total curative effective rate of patients in research group was higher than that in the control group,with statistical difference (P<0.05).The scores of primary symptom and secondary symptom in research group were lower than those in control group after treatment (P<0.05).The levels of ALT,AST and GGT of patients in research group were lower than those in control group after treatment,with statistical differences (P<0.05).There was no statistically significant difference between the two groups in the total incidence of adverse reactions (P＞0.05).
Conclusion
Wuzhi Dripping Pills combined with Entecavir in treatment of CHB has significant effects it can improve clinical symptoms and liver function,and have higher safety,which is worthy of clinical promotion and application.
2020 Vol. 27 (32): 50-52 [
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53
Value of red blood cell distribution width in prediction of fatality rate of patients with ST-segment elevation myocardial infarction after percutaneous coronary intervention
LIU Zeng-yong1 WU Feng2 ZHOU Zheng-qian3
Guide::
Objective
To investigate the value of red blood cell distribution width (RDW) in prediction of fatality rate of patients with ST-segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI).
Methods
The clinical data of 80 STEMI patients who were treated with PCI in Jingdezhen Second People′s Hospital from February 2017 to February 2019 were retrospectively analyzed.The clinical data of 18 dead patients during hospitalization were classified in observation group,and 62 survived patients during hospitalization were classified in control group.The levels of RDW,white blood cell count (WBC),cardiac troponin I (cTn-Ⅰ) were detected.Binary Logistic regression analysis was used to examine the effect of RDW level on the fatality rate of STEMI patients after PCI,and the area under the ROC curve was used to evaluate the predictive value of RDW and cTnⅠin fatality rate of STEMI patients after PCI.
Results
There was no statistical difference in the WBC level between two groups (P＞0.05).The levels of RDW and cTn-Ⅰin observation group were higher than those in control group,and the differences were statistically significant (P<0.05).Binary Logistic regression analysis showed that the RDW and cTn-Ⅰlevels were the risk factors for the fatality rate of STEMI patients after PCI (OR＞1,P<0.05).ROC curve showed that the AUC of RDW was 0.711 (95%CI：0.572-0.851),which was ≥0.7,with better predictive value.When the optimal cut-off value was 11.180,the ideal sensitivity and specificity can be obtained,which were 96.60%,85.50%,respectively.The AUC of cTn-Ⅰwas 0.657 (95%CI：0.520-0.794),0.5≤AUC<0.7,with lower predictive value,when the optimal cut-off value was 2.555,the ideal sensitivity and specificity can be obtained,which were 94.40%,58.10%,respectively.
Conclusion
Elevated RDW and cTn-Ⅰlevels are the risk factor for mortality in patients with STEMI after PCI.The higher the RDW and cTn-Ⅰlevels,the greater the risk of fatality rate in STEMI patients after PCI.Clinically,the patients with this condition should be given high attention.
2020 Vol. 27 (32): 53-55 [
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Clinical study of seamless rapid cooling pre-hospital and in-hospital for the treatment of thermoplegia
XIONG Tao JIN Yan XU Wen-peng
Guide::
Objective
To explore the clinical effect of seamless rapid cooling pre-hospital and in-hospital for the treatment of thermoplegia.
Methods
The clinical data of 45 patients with thermoplegia treated from July 2015 to November 2019 in Nanchang Third Hospital were retrospectively analyzed.According to different time points of starting rapid cooling,they were divided into observation group (n=24) and control group (n=21).After admission,patients in the control group received rapid cooling and multi-organ function support treatment;in the observation group,patients were provided with rapid cooling by the pre-hospital emergency staff and received the same treatment as the control group after admission.The time required the anal temperature to fall to 37°C,hospital stay,and the levels of creatinine (Cre),creatine kinase (CK),alanine aminotransferase (ALT) and prothrombin time (PT) were compared between the two groups.
Results
The time required for the anal temperature of the observation group to fall to 37℃,hospital stay,and PT were shorter than those of the control group,and the levels of Cre,CK,and ALT were lower than those of the control group,the differences were statistically significant (P<0.05).
Conclusion
By initiating a standardized pre-hospital emergency force,implementing rapid cooling for patients with thermoplegia as soon as possible can reduce the degree of organ damage and is conducive to improving the prognosis of patients.
2020 Vol. 27 (32): 56-58 [
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Application effect of Acetylcysteine for inhalation combined with Budesonide for inhalation in lung cancer patients with lower pulmonary function before and after surgery
OUYANG Zhi-cheng LIU Ping-xiang DONG Li-min
Guide::
Objective
To investigate the application effect of Acetylcysteine for inhalation combined with Budesonide for inhalation in lung cancer patients with lower pulmonary function before and after surgery.
Methods
A total of 40 lung cancer patients with lower pulmonary function who admitted in Pingxiang People′s Hospital from January 2018 to December 2019 were selected and divided into two groups according to random number table,20 cases in each group.The control group was given Budesonide for inhalation,and experimental group added Acetylcysteine.The pulmonary function (forced expiratory volume in first second [FEV
1
],forced expiratory volume in first second/forced vital capacity[FEV
1
/FVC],minute ventilation volume [MVV]),indexes of blood gas analysis (arterial partial pressure of oxygen [PaO
2
],arterial partial pressure of carbon dioxide [PaCO
2
]),hospital stays,use intensity and usage days of antibiotics,and complications were compared between two groups.
Results
The levels of FEV
1
and FEV
1
/FVC in experimental group were higher than those in control group after discharge for 1 month(P<0.05).The level of PaO
2
in experimental group was higher than that in control group after discharge for 1 month,the level of PaCO
2
in experimental group was lower than that in control group,the hospital stays and usage days of antibiotics in experimental group were shorter than those in control group,and the use intensity of antibiotics in experimental group was lower than that in control group,the differences were statistically significant (P<0.05).There was no statistical difference in the incidence of complications between two groups (P＞0.05).
Conclusion
Acetylcysteine inhalation combined with Budesonide inhalation in lung cancer patients with lower pulmonary function before and after surgery can improve pulmonary function and indexes of blood gas analysis,shorten hospital stays,and reduce the use of antibiotics,which has high safety and is worthy of clinical promotion.
2020 Vol. 27 (32): 59-61 [
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Efficacy of Tiotropium Bromide combined with Budesonide Formoterol in the treatment of chronic obstructive pulmonary disease
ZHU Yu-jun1 LIANG Qiu-hong2
Guide::
Objective
To investigate the efficacy of Tiotropium Bromide combined with Budesonide Formoterol in the treatment of chronic obstructive pulmonary disease (COPD).
Methods
A total of 88 patients with stable COPD admitted to Yichun People′s Hospital from January 2019 to January 2020 were selected and divided into two groups according to random number table method,44 cases in each group.The control group was treated with Budesonide Formoterol,and the observation group was treated with Tiotropium Bromide on the basis of the control group.The clinical efficacy,pulmonary function and adverse reactions were compared between the two groups.
Results
The total effective rate of the observation group was higher than that in the control group,the difference was statistically significant (P<0.05).Forced expiratory volumone second (FEV
1
),forced vital capacity (FVC),FEV
1
/FVC,interleukin-6 (IL-6),tissue inhibitor of metalloproteinase-1 (TIMP-1) and transforming growth factor-β (TGF-β) between two groups before treatment were compared,the differences had no statistically significant (P＞0.05).After treatment 3 months,in the observation group,FEV
1
was (2.71±0.45) mL,FVC was (3.11±0.39) mL,FEV
1
/FVC was (72.34±6.55)%,which were higher than those in the control of (2.26±0.43) mL,(2.57±0.19) mL,(62.21±7.51)%,after treatment 3 months,in the observation group,IL-6 was (15.06±6.03) ng/mL,TIMP-1 was (120.25±32.82) ng/mL,TGF-β was (79.54±9.24) ng/L,which were lower than those in the control group of (21.68±7.41) ng/mL,(145.11±33.18）ng/mL,(87.25±9.72) ng/L,the differences were statistically significant (P<0.05).There was significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).
Conclusion
Tiotropium Bromide combined with Budesonide Formoterol is effective in the treatment of COPD.It can improve the lung function and has high safety.It can be used as a safe and effective treatment for COPD patients.
2020 Vol. 27 (32): 62-65 [
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Application of target management model in patients with indwelling gastric tube after gastric cancer surgery
RAO Hong-ling
Guide::
Objective
To explore the application effect of target management model in patients with indwelling gastric tube after gastric cancer surgery.
Methods
A total of 80 patients with indwelling gastric tube after gastric cancer surgery in the First People′s Hospital of Fuzhou City from January 2018 to April 2020 were selected as the research objects and divided into the control group and the observation group by random number table method,with 40 cases in each group.The control group adopted the routine nursing plan,and the observation group used the target management model on the basis of the control group,and both groups were intervened for 7 days.The rehabilitation-related indicators,complications and quality of life were compared between the two groups.
Results
The exhaust time of first postoperative anal,time from liquid diet to semi-liquid diet and hospital stay time of the observation group were shorter than those of the control group,and the differences were statistically significant (P<0.05).the total complications rate of the observation group (10.00%) was lower than that of the control group (27.50%),and the difference was statistically significant (P<0.05).After 7 days of intervention,the quality of life scale (FACT-G) scores of the two groups were higher than those before intervention,and the differences were statistically significant (P<0.05).The FACT-G score of the observation group after 7 days of intervention was higher than that of the control group,and the difference was statistically significant (P<0.05).
Conclusion
The target management model is effective for patients with indwelling gastric tube after gastric cancer surgery,which can promote the recovery of patients,reduce the risk of complications,and improve the quality of life.
2020 Vol. 27 (32): 66-69 [
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Effect of laparoscopic radical treatment of colorectal cancer on the immune status of the body
LYU Yong-zhu WANG Da-wei▲ XU Cai REN Fei
Guide::
Objective
To investigate the effect of laparoscopic radical treatment of colorectal cancer on the immune status of the body.
Methods
A total of 80 patients with colorectal cancer who admitted to the Fifth People′s Hospital of Dalian City from January 2018 to December 2019 were selected as the study objects and divided into the control group and the study group according to the random number table method,with 40 patients in each group.The control group was treated with open surgery,while the study group was treated with laparoscopic radical resection of colorectal cancer.The T-lymphocyte subsets,serum immunoglobulin levels and inflammatory factors were compared between the two groups before and after 7 d of surgery.
Results
There were no statistically significant differences in the levels of CD3,CD4,CD8,CD4/CD8 before surgery between the study group ([57.55±4.13]%,[32.81±3.52]%,[27.51±3.24]%,1.11±0.25)and the control group ([57.52±4.24]%,[32.74±3.55]%,[27.55±3.41]%,1.12±0.12) (P>0.05).After 7 d of surgery,the levels of CD3,CD4,CD8,CD4/CD8 in the study group ([56.85±4.08]%,[31.02±4.10]%,[27.05±3.14]%,1.10±0.15) and the levels of CD3,CD4,CD8,CD4/CD8 in the control group ([50.58±3.79]%,[28.05±4.21]%,[25.79±4.12]%,1.01±0.22)were lower than those before surgery,and the differences were statistically significant (P<0.05).After 7 d of surgery,the levels of CD3,CD4,CD8,CD4/CD8 in the study group were higher than those in the control group,and the differences were statistically significant (P<0.05).There were no statistically significant differences in the levels of immunoglobulin G (IgG),immunoglobulin A (IgA) and immunoglobulin M (IgM) before surgery between the study group ([28.61±2.75],[157.24±21.58],[171.05±21.87]U/mL) and the control group ([28.58±2.68],[157.68±20.65],[170.98±25.41]U/mL) (P>0.05).After 7 d of surgery,the levels of IgG,IgA and IgM in the study group ([27.25±2.44],[145.78±19.68],[168.97±17.85]U/mL) and the levels of IgG,IgA and IgM in the control group ([26.45±3.21],[142.87±22.54],[164.21±16.85]U/mL) were lower than those before surgery,and the differences were statistically significant (P<0.05).After 7 d of surgery,the levels of IgG,IgA and IgM in the study group were higher than those in the control group,and the differences were statistically significant (P<0.05).There were no statistically significant differences in the levels of interleukin-6 (IL-6),C-reactive protein (CRP) and tumer necrosis factor-α (TNF-α) before surgery between the study group ([17.92±4.68]ng/L,[5.18±1.22]mg/L],[33.64±6.78]ng/mL) and the control group ([17.85±5.32]ng/L,[5.12±1.51]mg/L,[33.58±8.15]ng/mL) (P>0.05).After 7 d of surgery,the levels of IL-6,CRP and TNF-α in the study group([32.89±5.25]ng/L,[18.65±4.78]mg/L,[44.27±5.62]ng/mL) and the levels of IL-6,CRP and TNF-α in the control group ([55.87±7.25]ng/L,[38.65±8.95]mg/L,[50.58±10.52]ng/mL) were higher than those before surgery,and the differences were statistically significant (P<0.05).After 7 d of surgery,the levels of IL-6,CRP and TNF-α in the study group were lower than those in the control group,and the differences were statistically significant (P<0.05).
Conclusion
Laparoscopic radical treatment of colorectal cancer can reduce the impact on the immune status of the body,and it is worthy of clinical promotion and application.
2020 Vol. 27 (32): 70-72 [
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