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| Effect of laparoscopic radical treatment of colorectal cancer on the immune status of the body |
| LYU Yong-zhu WANG Da-wei▲ XU Cai REN Fei |
| The Second Department of General Surgery,the Fifth People′s Hospital of Dalian City,Liaoning Province,Dalian 116021,China |
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Abstract Objective To investigate the effect of laparoscopic radical treatment of colorectal cancer on the immune status of the body.Methods A total of 80 patients with colorectal cancer who admitted to the Fifth People′s Hospital of Dalian City from January 2018 to December 2019 were selected as the study objects and divided into the control group and the study group according to the random number table method,with 40 patients in each group.The control group was treated with open surgery,while the study group was treated with laparoscopic radical resection of colorectal cancer.The T-lymphocyte subsets,serum immunoglobulin levels and inflammatory factors were compared between the two groups before and after 7 d of surgery.Results There were no statistically significant differences in the levels of CD3,CD4,CD8,CD4/CD8 before surgery between the study group ([57.55±4.13]%,[32.81±3.52]%,[27.51±3.24]%,1.11±0.25)and the control group ([57.52±4.24]%,[32.74±3.55]%,[27.55±3.41]%,1.12±0.12) (P>0.05).After 7 d of surgery,the levels of CD3,CD4,CD8,CD4/CD8 in the study group ([56.85±4.08]%,[31.02±4.10]%,[27.05±3.14]%,1.10±0.15) and the levels of CD3,CD4,CD8,CD4/CD8 in the control group ([50.58±3.79]%,[28.05±4.21]%,[25.79±4.12]%,1.01±0.22)were lower than those before surgery,and the differences were statistically significant (P<0.05).After 7 d of surgery,the levels of CD3,CD4,CD8,CD4/CD8 in the study group were higher than those in the control group,and the differences were statistically significant (P<0.05).There were no statistically significant differences in the levels of immunoglobulin G (IgG),immunoglobulin A (IgA) and immunoglobulin M (IgM) before surgery between the study group ([28.61±2.75],[157.24±21.58],[171.05±21.87]U/mL) and the control group ([28.58±2.68],[157.68±20.65],[170.98±25.41]U/mL) (P>0.05).After 7 d of surgery,the levels of IgG,IgA and IgM in the study group ([27.25±2.44],[145.78±19.68],[168.97±17.85]U/mL) and the levels of IgG,IgA and IgM in the control group ([26.45±3.21],[142.87±22.54],[164.21±16.85]U/mL) were lower than those before surgery,and the differences were statistically significant (P<0.05).After 7 d of surgery,the levels of IgG,IgA and IgM in the study group were higher than those in the control group,and the differences were statistically significant (P<0.05).There were no statistically significant differences in the levels of interleukin-6 (IL-6),C-reactive protein (CRP) and tumer necrosis factor-α (TNF-α) before surgery between the study group ([17.92±4.68]ng/L,[5.18±1.22]mg/L],[33.64±6.78]ng/mL) and the control group ([17.85±5.32]ng/L,[5.12±1.51]mg/L,[33.58±8.15]ng/mL) (P>0.05).After 7 d of surgery,the levels of IL-6,CRP and TNF-α in the study group([32.89±5.25]ng/L,[18.65±4.78]mg/L,[44.27±5.62]ng/mL) and the levels of IL-6,CRP and TNF-α in the control group ([55.87±7.25]ng/L,[38.65±8.95]mg/L,[50.58±10.52]ng/mL) were higher than those before surgery,and the differences were statistically significant (P<0.05).After 7 d of surgery,the levels of IL-6,CRP and TNF-α in the study group were lower than those in the control group,and the differences were statistically significant (P<0.05).Conclusion Laparoscopic radical treatment of colorectal cancer can reduce the impact on the immune status of the body,and it is worthy of clinical promotion and application.
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