|
|
|
| Influence of hypertension on vascular endothelial function and homocysteine level in patients with acute cerebral infarction |
| PENG Xiao-yu |
| Department of Functional Ispection,the Fourth Affiliated Hospital of Nanchang University,Jiangxi Province,Nanchang 330003,China |
|
|
|
|
Abstract ObjectiveTo observe and analyze the influence of hypertension on vascular endothelial function and homocysteine level in patients with acute cerebral infarction.MethodsFrom June 2014 to June 2016,200 patients with acute cerebral infarction in Department of Neurology in our hospital were selected for study.According to whether hypertension was combined or not,they were divided into cerebral infarction with normal blood pressure group(normal group)and cerebral infarction group with hypertension group(combined group),and 100 cases were in each group.At the same time, another group of 100 healthy people for physical examinations were selected as control group.FMD of brachial artery, IMT,and levels of Hcy,NO,and eNOS were retrospectively analyzed and their relationships were comprehensively analyzed.ResultsThe levels of carotid IMT and serum Hcy in the normal group and the combined group were significantly higher than those in the control group (P＜0.05).The levels of FMD,serumNO,andeNOS were greatly lower than those in the control group,the difference was statistically significant(P＜0.05).The levels of carotid IMT and serum Hcy in the combined group were much higher than those in the normal group(P＜0.05).The levels of FMD,serumNO,andeNOS were significantly lower than those in the normal group,the difference was statistically significant(P＜0.05).The Spearman linear correlation analysis showed that there were negative correlations between IMT and serum NO,and between IMT and eNOS level in the normal group and combined group(P＜0.05),but a positive correlation with serum Hcy level(P＜0.05).The FMD was positively correlated with the levels of serum NO and eNOS in the normal group and combined group(P＜0.05),but negatively correlated with serum Hcy level(P＜0.05).Conclusion There are vascular endothelial dysfunction and homocysteinemia in patients with acute cerebral infarction,and both of them have important synergistic relationship with the occurrence and development of acute cerebral infarction together with hypertension.Early ultrasound measurement of IMT and FMD can predict the occurrence of cerebral infarction.
|
|
|
|
|
|
| [1] |
赵旭，王鹏，区腾飞，等.同型半胱氨酸对急性脑梗死病人血管内皮功能的影响[J].中西医结合心脑血管病杂志，2016，14（20）：2433－2435.
|
| [2] |
陈锋，乔晋，张力.叶酸对老年高血压病患者的临床疗效及对血浆同型半胱氨酸与血管内皮功能的影响[J].河北医学，2016，22（10）：1607－1610.
|
| [3] |
徐雄鹰，周蓉靖，白春峰，等.H型高血压合并急性脑梗死患者血浆同型半胱氨酸水平与颈动脉内膜中层厚度的关系[J].中华高血压杂志，2015，17（4）：383－386.
|
| [4] |
王艾，谭博，张爱玲，等.同型半胱氨酸对脑梗死患者血管内皮细胞功能的影响[J].检验医学与临床，2015，23（1）：121－123.
|
| [5] |
朱明辉，胡广奋，陆婉晖，等.血清同型半胱氨酸水平对首发急性脑梗死患者短期预后的影响[J].临床和实验医学杂志，2015，28（5）：375－378.
|
| [6] |
曲东锋，李宏建，陈兴洲.“第四届国际脑血管疾病研究进展学术交流会”纪要[J].国际脑血管病杂志，2003，11（6）：477－478.
|
| [7] |
王蕾，陈哲萌，陈浩，等.高血压合并脑梗死患者同型半胱氨酸与颈动脉硬化相关性研究[J].中华全科医学，2015，13（8）：1270－1272.
|
| [8] |
江波，徐士良，张红香.急性脑梗死患者血管内皮功能和同型半胱氨酸水平变化及治疗分析[J].中国实用神经疾病杂志，2014，（23）:105－107.
|
| [9] |
周海波，洪梅，李燕，等.血浆同型半胱氨酸水平对女性高血压患者冠状动脉病变及左心室功能的影响[J].江苏医药，2017，43（4）：261－264.
|
| [10] |
寇雪莲，陈琳迪，何松彬，等.高同型半胱氨酸血症对急性脑梗死患者预后的影响[J].中华全科医学，2015，13（5）：697－699.
|
| [11] |
翟德林，李慧.叶酸干预治疗对H型高血压患者血浆同型半胱氨酸血压水平及主要心脑血管事件的影响[J].山西医药杂志，2015，37（14）：1672－1674.
|
| [12] |
张林，郑培华.同型半胱氨酸水平与急性脑梗死患者近期临床预后的关系[J].实用临床医药杂志，2016，20（21）：183－184.
|
| [13] |
王洲羿，周刚，李钢，等.叶酸和维生素B12联合治疗对血管性痴呆伴H型高血压患者血浆Hcy、炎性因子水平及血管壁内皮功能的影响[J].海南医学院学报，2017，23（5）：713－716.
|
| [14] |
张秀洲，刘福艳，李静，等.血管内皮功能和同型半胱氨酸对老年冠心病患者发病的相关性探讨[J].中华老年心脑血管病杂志，2015，17（12）：1268－1270.
|
| [15] |
曹昌权，刘维洲.急性脑梗死患者血浆同型半胱氨酸水平高血压与脑微出血的相关性分析[J].安徽医学，2015，36（6）：717－720.
|
|
|
|
