补肾通络法联合阿仑磷酸钠治疗强直性脊柱炎合并骨质疏松的临床效果

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Abstract Objective To explore the clinical effect of Bushen Tongluo method combined with Alendronate Sodium in the treatment of ankylosing spondylitis with osteoporosis.Methods Eighty patients with ankylosing spondylitis (AS) and osteoporosis (OP) admitted to our hospital from August 2017 to June 2018 were selected and divided into the control group (40 cases) and the intervention group (40 cases) according to the random number table method.The control group was treated with Alendronate Sodium.The intervention group was treated combined with Bushen Tongluo method.The bone mineral density (BMD) of the lumbar vertebrae (L2-4),femoral neck and greater trochanter before and after treatment,bone-carboxyglutamate protein (BGP),procollagen type Ⅰamino-terminal prolonging peptide (PⅠNP),carboxyterminal telopeptide of type Ⅰcollagen (CTX) content were compared between the two groups,and the total clinical effectiveness after treatment was observed.Results After treatment,the BMD of L2-4,femoral neck and greater trochanter were higher than those before treatment.The BGP and PⅠNP levels of the two groups were higher than those before treatment,and the CTX level was lower than that before treatment.The BMD of L2-4,femoral neck and greater trochanter of the intervention group were higher than those of the control group.The BGP and PⅠNP levels in the intervention group were higher than those in the control group,and the CTX level was lower than that in the control group,the differences were statistically significant (P＜0.05).The total effective rate of the intervention group was 92.50%,which was higher than that of the control group (75.00%),and the difference was statistically significant (P＜0.05).Conclusion The combination of Bushen Tongluo method and Alendronate Sodiumin in the treatment of patients with AS and OP can significantly improve clinical efficacy and improve bone metabolism and BMD.

Key words： Ankylosing spondylitis Osteoporosis Bushen Tongluo method Alendronate Sodium Bone metabolism;Bone mineral density

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CHEN Nian. Clinical effect of Bushen Tongluo method combined with Alendronate Sodium in the treatment of ankylosing spondylitis with osteoporosis[J]. 中国当代医药, 2020, 27(1): 115-117转120.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I1/115

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