美托洛尔在治疗脓毒性休克患者中的应用效果

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Abstract Objective To investigate the effect of Metoprolol in the treatment of patients with septic shock.Methods From July 1,2017 to March 31,2019,40 patients with septic shock admitted to Yangjiang Traditional Chinese Medicine Hospital,Zhujiang Hospital in Guangzhou City and Yangchun People′s Hospital were selected as research objects,the patients were divided into conventional treatment group and Metoprolol group by random number table method,with 20 cases in each group.Patients in the conventional treatment group received routine treatment,while patients in the Metoprolol group received Metoprolol treatment on the basis of routine treatment.The heart rate,mean arterial pressure,central venous pressure (CVP),central venous oxygen saturation (ScvO2) and urine volume before and after treatment were compared between the two groups.The cardiac index (CI) and peripheral vascular resistance index(SVRI) of the two groups were compared at different time after treatment (4,8,16,24,36,48,72,96 h after treatment).The incidence of heart failure and death in 28 d were compared between the two groups.Results Before treatment,there were no significant difference in heart rate,mean arterial pressure,CVP,ScvO2,urine volume,CI and SVRI between the two groups (P>0.05).There was no significant difference in the mean arterial pressure between the two groups before and after treatment (P>0.05).The heart rate of Metoprolol group after treatment was slower than that before treatment,the difference was statistically significant (P<0.05).There was no significant difference in heart rate before and after treatment in conventional treatment group (P>0.05).After treatment,the CVP,ScvO2 and urine volume of the two groups of patients were higher than before treatment,the differences were statistically significant (P<0.05).After treatment,the heart rate of Metoprolol group was slower than that of the conventional treatment group,and the CVP,ScvO2 and urine volume were higher than those of the conventional treatment group,the differences were statistically significant (P<0.05).There was no significant difference in the mean arterial pressure between the two groups (P>0.05).There were no significant difference between the two groups in CI (4,8,16,24,36,48,72,96 h after treatment) and SVRI (8,16,24,36,48,72,96 h after treatment) (P>0.05).SVRI of Metoprolol group was lower than that of conventional treatment group 4 h after treatment,the difference was statistically significant (P<0.05).The incidence of heart failure(40.0%) and 28 d mortality (10.0%) in Metoprolol group were lower than those in conventional treatment group (75.0%and 40.0%),the differences were statistically significant (P<0.05).Conclusion The application of Metoprolol to sepsis on the basis of full fluid resuscitation and stable hemodynamics can effectively reduce heart rate,heart failure rate and 28 d mortality,which is worthy of promotion.

Key words： Septic shock Metoprolol Heart rate 28 d mortality

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	Articles by authors
	CHEN Da-yang
	GAO Yong-you
	CEN Zhong-ran
	GUAN Yuan-zhi

Cite this article:

CHEN Da-yang,GAO Yong-you,CEN Zhong-ran, et al. Application effect of Metoprolol in the treatment of patients with septic shock[J]. 中国当代医药, 2019, 26(27): 102-105.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I27/102

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