噻托溴铵联合沙美特罗替卡松吸入治疗矽肺并发慢性阻塞性肺疾病的临床效果

Abstract
Figure/Table
References (18)
Related Citation (15)

Download: PDF (0 KB) HTML (39 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the clinical efficacy of Tiotropium Bromide combined with Salmeterol and Fluticasone Inhalation in the treatment of silicosis complicated with chronic obstructive pulmonary disease.Methods From January 2017 to October 2018,60 patients with silicosis and chronic obstructive pulmonary disease in stable stage treated in Ping Ming General Hospital of Pingxiang City in Jiangxi Province were selected.They were divided into the control group,the observation group and the treatment group according to random number table methods.The control group was given symptomatic treatment,while the observation group was given Tiotropium Bromide Powder inhalation on the basis of the above treatment.On the basis of the observation group,the treatment group received regular inhalation of Salmeterol and Roticasone Inhalation.After 3 months,all subjects completed lung function detection again,such as forced vital capacity (FVC),forced expiratory volume (FEV1),FEV1/FVC,the percentage of forced expiratory volume in the first second to the normal predicted value (FEV1%),and the walking distance of the 6-minute walking test was measured.Results The results of FVC,FEV1,FEV1/FVC,FEV1% and 6-minute walking test in the treatment group after intervention were higher than those in the observation group and the control group,the differences were statistically significant (P＜0.05).The results of FVC,FEV1,FEV1% and 6-minute walking test in the observation group after intervention were higher than those in the control group,the differences were statistically significant (P＜0.05).Conclusion Tiotropium Bromide combined with Salmeterol and Fluticasone Inhalation is effective in the treatment of silicosis complicated with chronic obstructive pulmonary disease.The pulmonary function of patients recovers better.The walking distance of 6-minute walking test is longer,which can be used as the optimal treatment.

Key words： Tiotropium Bromide Salmeterol and Fluticasone Silicosis Chronic obstructive pulmonary disease

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LI Ming
	ZHANG Zu-hua

Cite this article:

LI Ming,ZHANG Zu-hua. Clinical effect of Tiotropium Bromide combined with Salmeterol and Fluticasone Inhalation in the treatment of silicosis complicated with chronic obstructive pulmonary disease[J]. 中国当代医药, 2019, 26(27): 47-50.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I27/47

[1]	李玉洁，贾晓民.矽肺的治疗进展[J].临床肺科杂志，2017，22（6）：1119-1122.
[2]	Rando RJ，Vacek PM，Glenn RE，et al.Retrospective assessment of respirable quartz exposure for a silicosis study of the industrial sand industry[J].Ann Work Expo Health，2018，62（8）：1021-1032.
[3]	刘亚，刘娴，余志斌，等.矽肺合并慢性阻塞性肺疾病患者的肺功能及血气分析[J].中国当代医药，2018，25（6）：111-113.
[4]	Nandi S，Burnase N，Barapatre A，et al.Assessment of silicosis awareness among stone mine workers of rajasthan state[J].Indian J Occup Environ Med，2018，22（2）：97-100.
[5]	樊乃根.矽肺发病及治疗研究的最新进展[J].职业与健康，2016，32（8）：1140-1142.
[6]	Volobaev VP，Larionov AV，Kalyuzhnaya EE，et al.Associations of polymorphisms in the cytokine genes IL-1β （rs169 44），IL-6 （rs1800795），IL-12b （rs3212227）and growth factor VEGFA （rs2010963） with anthracosilicosis in coal miners in Russia and related genotoxic effects[J].Mutagenesis，2018，33（2）：129-135.
[9]	刘瑞莹.矽肺并发慢性阻塞性肺疾病治疗探讨[J].临床肺科杂志，2013，18（8）：1511-1512.
[10]	刘文华.噻托溴铵治疗尘肺并发慢性阻塞性肺疾病的效果[J].临床医药文献电子杂志，2018，5（8）：159.
[11]	侯婷婷，靳玉梅，窦红，等.噻托溴铵治疗尘肺并发慢性阻塞性肺疾病对患者肺功能、血气指标及气道炎症的影响[J].中国临床研究，2017，30（11）：1501-1504.
[7]	Panev NI，Zakharenkov VV，Korotenko OY，et al.Diagnostic features of atherosclerosis development in miners having anthracosilicosis[J].Med Tr Prom Ekol，2016，9（5）：16-20.
[8]	Spalgais S，Gothi D，Jaiswal A，et al.Nonoccupational anthracofibrosis/anthracosilicosis from Ladakh in Jammu and Kashmir，India：a case series[J].Indian J Occup Environ Med，2015，19（3）：159-166.
[12]	李艳丽.噻托溴铵治疗尘肺并发慢性阻塞性肺疾病的效果[J].临床医学研究与实践，2016，1（13）：68.
[13]	陈逸心.沙美特罗替卡松干粉与噻托溴铵粉联合吸入治疗矽肺并发哮喘的临床分析[J].医学理论与实践，2015，28（2）：192-193.
[14]	Alaya Z，Braham M，Aissa S，et al.A case of Caplan syndrome in a recently diagnosed patient with silicosis：a case report[J].Radiol Case Rep，2018，13（3）：663-666.
[15]	李赞华，刘晓俊，陈艳玲，等.联合吸入治疗矽肺并中重度慢性阻塞性肺疾病的临床研究[J].江西医药，2017，52（4）：283-285，289.
[16]	史卫卫，刘璐，张帆，等.慢性阻塞性肺疾病患者CAT 评分与病情评估指标的相关性分析[J].老年医学与保健，2018，24（3）：257-261.
[17]	李学任，赵俭，董彦，等.6 分钟步行试验在慢性呼吸系统疾病中的应用进展[J].武警后勤学院学报（医学版），2018，27（2）：181-184.
[18]	王焕，陈刚，孙志谦，等.中国煤矿工人北戴河疗养院入院治疗的165 例矽肺患者矽肺进展危险因素分析[J].职业与健康，2018，34（3）：309-312.