地塞米松联合丙种球蛋白治疗小儿过敏性紫癜性肾炎的临床观察

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Abstract Objective To investigate the clinical effect of Dexamethasone combined with Gamma Globulin in the treatment of children with Henoch-Schonlein purpura nephritis (HSPN).Methods The clinical data of 50 children with HSPN who were treated in our hospital from March 2014 to March 2017 were analyzed,all the patients were divided into the control group (n=20)and observation group (n=30)according to different treatment methods.The control group was treated with Dexamethasone,while the observation group was treated with Dexamethasone combined with Gamma Globulin.The pre-operative and post-operative fibrinogen(FIB),prothrombin time(PT),activated partial thromboplastin time(APTT),24 h urine protein and urine red blood cell levels of two groups were observed,and the clinical efficacy of the two groups was observed.Results The pre-operative and post-operative PT of two groups had no statistically significant difference (P＞0.05).The pre-operative FIB,APTT,24 h urine protein and urine red blood cell levels of two groups had no statistically significant difference(P＞0.05).The post-operative FIB of control group and observation group were(2.9±0.3)g/L and(2.0±0.2)g/L respectively,the 24 h urine protein were(0.14±0.03)g and(0.10±0.02)g respectively,the urine red blood cell levels were(1.9±0.4)×107 and(1.1±0.5)×107respectively,which were both lower than pre-operative levels of FIB ([3.6±0.2]g/L,[3.7±0.3]g/L),the 24 h urine protein([0.18±0.05]g,[0.19±0.06]g),the urine red blood cell([4.8±0.4]×107,[4.7±0.5]×107)respectively,the post-operative APTT of control group and observation group were (26.0±1.8)s and (28.9±2.1)s respectively,which were higher than pre-operative levels of APTT ([24.0±2.2]s,[23.9±2.0]s)respectively,while the post-operative FIB,24 h urine protein and urine red blood cell levels of the observation group were lower than those of the control group,and the postoperative APTT of the observation group was higher than that of the control group,the differences were statistically significant(P＜0.05).The total effective rate of the observation group was 96.7%,which was higher than that of the control group(80.0%),with statistically significant difference(P＜0.05).Conclusion Application of combination of dexamethasone and gamma globulin in the treatment of children with Henoch-Schonlein purpura nephritis has good effect and significant improvement in coagulation function,24h urinary protein and urine red blood cell levels,which is worthy of clinical application.

Key words： Dexamethasone Gamma Globulin Children Henoch-Schonlein purpura nephritis Coagulation function 24 h urine protein Urine red blood cell

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	XIE Jin-jin
	XIAO Zhen
	YUAN Hong-ling

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XIE Jin-jin,XIAO Zhen,YUAN Hong-ling. Clinical observation of Dexamethasone combined with Gamma Globulin in the treatment of children with Henoch-Schonlein purpura nephritis[J]. 中国当代医药, 2018, 25(10): 140-143.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I10/140

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