雾化吸入联合常规治疗对新生儿吸入性肺炎的效果和细胞因子的影响分析

Abstract
Figure/Table
References (16)
Related Citation (15)

Download: PDF (2238 KB) HTML (30 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To evaluate the effect of aerosol inhalation combined with conventional therapy on neonatal aspiration pneumonia and cytokines.Methods 99 neonates with inhalation pneumonia treated in our hospital from March 2015 to March 2017 were randomly divided into control group,observation group and experimental group.33 cases in each group were given routine treatment of control group.the observation group was treated with aerosol inhalation of ambroxol combined with routine treatment.the experimental group was treated with budesonide aerosol inhalation on the basis of routine treatment.the clinical efficacy,PO2/FiO2value and interleukin-6 level of the three groups were observed and compared.Results The disappearance time and average hospitalization time of main symptoms in the observation group and the experimental group were shorter than those in the control group(P＜0.05).After the treatment,the total effective rate of the experimental group and the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05).During the treatment,PO2/FiO2in the observation group and the experimental group were significantly higher than those in the control group at different time periods(P＜0.05).After the treatment,the levels of Interleukin-6 in the three groups were decreased,and the levels of Interleukin-6 in the observation group and the experimental group were lower than those in the control group,the difference was statistically significant(P＜0.05).Conclusion Aerosol inhalation for neonatal aspiration pneumonia can significantly improve efficacy,ameliorate lung ventilation function and shorten oxygen-dependent time.The study also indicates the higher the level of interleukin-6 measures,the lower the PaO2/FiO2,and the more severe pulmonary ventilation dysfunction becomes,which has a clinical application value.

Key words： Budesonide Ambroxol Aerosol inhalation Neonatal aspiration pneumonia Interleukin-6

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	YE Ming-yi
	CHEN Wei-zhong
	HUANG Jun-ye
	WANG Yu

Cite this article:

YE Ming-yi,CHEN Wei-zhong,HUANG Jun-ye, et al. Effect of aerosol inhalation combined with routine therapy on neonatal aspiration pneumonia and cytokines[J]. 中国当代医药, 2018, 25(10): 127-129转136.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I10/127

[1]	郑霞飞.沐舒坦在新生儿胎粪吸入性肺炎治疗中的疗效探讨[J].当代医学，2014，20（10）：130-131.
[2]	李培燕.78例新生儿吸入性肺炎的临床诊疗分析[J].河北医科大学学报，2015，12（2）：159-161.
[4]	庞爱华.猪肺磷脂注射液治疗新生儿重症胎粪吸入性肺炎的效果观察[J].河南医学研究，2017，26（18）：3392-3393.
[5]	Kanter M，Sahin SH，Basaran UN，et al.The effect of methylene blue treatment on aspiration pneumonia[J].J Surg Res.2015，193（2）：909-919.
[6]	叶晖勇.雾化吸入、静脉滴注氨溴索治疗新生儿胎粪吸入性肺炎的临床效果比较[J].中国当代医药，2015（19）：119-121.
[7]	杨迪元，沈莉荣，于真爱，等.糖皮质激素治疗胎粪吸入综合征疗效和安全性的Meta分析[J].中国循证儿科杂志，2011，6（2）：126-134.
[8]	邵肖梅，叶鸿瑁，丘小汕.实用新生儿学[M].4版.北京：人民卫生出版社，2011：341-342.
[9]	梁粤，李敬衡，罗遥，等.肺炎患儿应用布地奈德雾化吸入治疗的临床疗效研究[J].中华医院感染学杂志，2016，26（4）：928-929.
[10]	马丽.普米克令舒联合氨溴索雾化治疗新生儿肺炎疗效观察[J].中国医学创新，2014，11（1）：53-55.
[11]	Bausewein C，Simon ST.Inhaled nebulized and intranasal opioidsforthereliefofbreathlessness[J].CurrOpinSupportPa，2014，8（3）：208-212.
[12]	段捷华，覃睿.盐酸氨溴索注射液在国内儿科临床的应用进展[J].医学综述，2015，21（8）：1438-1440.
[13]	范倩倩，张波，李大魁，等.注射用盐酸氨溴索的临床应用现状与思考[J].中国药学杂志，2015，50（9）：816-820.
[14]	叶明伟.布地奈德联合氨溴索雾化吸入治疗小儿支气管肺炎的疗效研究[J].中华医院感染学杂志，2013，23（1）：100-102.
[15]	黄立敏.护理干预联合布地奈德雾化吸入辅助治疗小儿急性喉炎 31 例[J].中国药业，2013，22（11）：77-79.
[16]	邓春晖，姚毅.常规疗法与布地奈德雾化吸入法治疗小儿肺炎的疗效对比分析[J].临床肺科杂志，2014，19（2）：298-300.