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| Changes of renal tubular related indexes in IgA nephropathy combined with hyperuricemia |
| LIU Ye-wei1 SUN Ming1 SUN Yi-jun1 WU Wen-bin2▲ |
1.Clinical College of Weifang Medical University in Shandong Province,Weifang 261053,China;
2.Department of Nephrology,Yidu Central Hospital of Weifang City in Shandong Province,Weifang 262500,China. |
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Abstract Objective To investigate the changes of renal tubular related index in patients with hyperuricemia IgA nephropathy,and understand the impact of high uric acid on renal tubules.Methods A total of 105 patients with primary IgA nephropathy treated in Yidu Central Hospital of Weifang from February 2014 to January 2016 were selected as the subjects,and divided into normal uric acid group(n=55)and hyperuricemia group(n=50).The urinary β2-microglobulin(β2-MG),N-acetyl-β-D-glucosaminidase(NAG),Retinol-binding protein(RBP),titratable acid(TA),urinary ammonium ion(NH4+),urine osmotic pressure(UOSM)were observed.Results The urinary β2-MG,RBP and NAG in high uric acid group were significantly higher than those in normal uric acid group,the difference was statistically significant(P＜0.01).There was no significant difference in urine TA,NH4+and UOSM between the two groups(P＞0.05).Conclusion Hyperuricemia has obvious damage to the proximal tubules of patients with IgA nephropathy,but it has little effect on the acidification and concentration and dilution of distal tubules.
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| [1] |
郭宗运，工营营，李慧，等.表现为微量自蛋自尿IgA肾病预后的危险因素分析[J].中国医师杂志，2015，17（11）：1694-1697.
|
| [2] |
Moriyama T，Itabashi M，Takei T，et al.High uric acid level is a risk factor for progression of IgA nephropathy with chronic kidney disease stage G3a[J].J Nephrol，2015，28（4）：451-456.
|
| [3] |
王心，陈铖.伴高尿酸血症的原发性IgA肾病的临床及病理特征分析[J].东南国防医药，2017，19（6）：600-603
|
| [4] |
Moriyama T，Tanaka K，Iwasaki C，et al.Prognosis in IgA nephropathy：30-year analysis of 1 012 patients at a single center in Japan[J].PloS one，2014，9（3）：e91756.
|
| [5] |
Zeng CH，Le W，Ni Z，et al.A multicenter application and evaluation of the oxford classification of IgA nephropathy in adult chinese patients[J].Am J Kidney Dis，2012，60（5）：812-820.
|
| [6] |
蔡伟程，韩蜀莲，郭晓丹，等.IgA肾病合并高尿酸血症患者的临床病理分析[J].临床肾脏病杂志，2016，16（3）：152-156.
|
| [7] |
Syrjonen J，Mustonen J.Hypertriglyceridaemia and hyperuricaemia are risk factors for progression of IgA nephropathy[J].Nephrol Dial Transplant，2000，15（1）：34-42.
|
| [8] |
Zhou J，Chen Y，Liu Y，et al.Plasma uric acid level indicates tubularinterstitialleisionsatearlystageofIgAnephropathy[J].BMC nephrology，2014，14（15）：11.
|
| [9] |
赵曼均，金济福，章晓燕，等.IgA肾病合并高尿酸血症患者的临床和病理学分析[J].上海医学，2016，39（5）：265-271.
|
| [10] |
Sánchez-Lozada LG，Tapia E，López-Molina R，et al.Effects of acute and chronic L-arginine treatment in experimental hyperuricemia[J].Am J physiol.Renal Physiol，2007，292（4）：1238-1244.
|
| [11] |
王晓燕.血清胱抑素C、β2-微球蛋白、视黄醇结合蛋白、尿微量白蛋白及N-乙酰-β-D-氨基葡萄糖苷酶在诊断糖尿病早期肾损伤中的临床意义[J].新乡医学院学报，2017，34（2）：143-146.
|
| [12] |
刘发河，黎景梨，曾海莲，等.尿渗透压与尿生化指标在慢性肾炎诊断中的意义[J].广东医学院学报，2016，34（5）：504-507.
|
| [13] |
刘晓峰，熊鹰，徐莹.尿视黄醇结合蛋白、尿微量白蛋白、尿β2微球蛋白、尿NAG酶联合检测在糖尿病早期肾损伤诊断中的意义[J].中国卫生检验杂志，2017，27（10）：1474-1475，1478.
|
| [14] |
南京柱，李娟，高静，等.生化及免疫指标在IgA肾病Lee氏分级中的应用价值[J].中华检验医学杂志，2016.39（9）：695-700.
|
| [15] |
张晓丽，张金梅，武文斌，等.肾炎舒颗粒对早期糖尿病肾病患者尿足细胞及肾小管功能的影响[J].山东医药，2016，56（33）：75-77.
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