降钙素原和C反应蛋白在新生儿败血症早期诊断中的价值

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Abstract ObjectiveTo explore the clinical value of dection procalcitonin(CRP)and C reactive protein(PCT)in early diagnosis neonatal sepsis.Methods113 newborn cases were collected in Chuzhou branch of Nanjing children′s hospital from January 2015 to December 2016 and were selected as the research objects and divided into the sepsis group(91 cases)and non-infected group (22 cases)according to the diagnostic criteria for neonatal septicemia and whether infection was occurred.The levels of PCT and CRP between the sepsis group and non-infected group were compared,the levels of PCT of 32 children in the sepsis group before and after treatment were compared,the sensitivity,specificity,positive predictive value and negative predictive value of PCT and CRP in the diagnosis of neonatal sepsis were analyzed.ResultsThe levels of the PCT and CRP in the sepsis group were higher than those in the non-infected group,and the differences were statistically significant(P＜0.05).The PCT level of 32 children with septicemia after treament was significantly lower than before treatment,and the difference was statistically significant (P＜0.01).The sensitivity of PCT≥2 μg/L to the diagnosis of neonatal sepsis was 74.74%,specificity was 100.00%,the sensitivity of CRP≥8 mg/L to the diagnosis of neonatal sepsis was 54.95%,and the specificity was 81.82%.ConclusionThere are clinical value of detection CRP and PCT in early diagnosis neonatal sepsis and the effect of treatment.Detected PCT combine with CRP were valuable to improve sensitivity and specificity in diagnosis neonatal sepsis.

Key words： Procalcitonin C reactive protein Neonatal sepsis Diagnosis

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