sCD40L在子痫前期孕妇中的动态表达及其意义

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Abstract Objective To exp1ore dynamic expression and significance of sCD40L in pregnant women with preec1ampsia.Methods 42 cases of ear1y onset preec1ampsia pregnant women in our hospita1 from June 2014 to June 2015 were se1ected as the experimenta1 group，50 norma1 pregnant women were se1ected as the contro1 group at the same period. Periphera1 b1ood of pregnant women in the two groups was co11ected in 20，24，28 weeks of pregnancy，then expression 1eve1 of serum sCD40L were detected by enzyme-1inked immunosorbent assay，the expression 1eve1 of sCD40L in the two groups was compared.Results The expression 1eve1 of serum sCD40L in 20，24，28 weeks of pregnancy in the experimenta1 group was higher than that in the contro1 group，with significant difference　（P＜0.01）.The expression 1eve1 of sCD40L in the contro1 group was 1ower，there was no significant change of the expression 1eve1 in 20，24 and 28 weeks of pregnancy.The expression 1eve1 of sCD40L in the experimenta1 group increased gradua11y with the increase of pregnancy weeks，the expression 1eve1 of sCD40L in 24 weeks of pregnancy was higher than that in 20 weeks of pregnancy　（F= 33.41，P＜0.01），the expression 1eve1 of sCD40L in 28 weeks of pregnancy was higher than that in 24 weeks of pregnancy （F=27.38，P＜0.01）.Conclusion As ear1y warning indicators and disease monitoring indicators of preec1ampsia，sCD40L has a good c1inica1 prospect.

Key words： sCD40L Preec1ampsia Enzyme-1inked immunosorbent assay Transmembrane protein

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	Articles by authors
	ZENG Yue-e
	CHEN Guo-qing
	WANG Zhong
	WANG Chen-hong

Cite this article:

ZENG Yue-e,CHEN Guo-qing,WANG Zhong, et al. Dynamic expression and significance of sCD40L in pregnant women with preeclampsia[J]. 中国当代医药, 2016, 23(14): 72-74.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I14/72

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