Objective To exp1ore the effect of sedation and ana1gesia of dexmedetomidine combined with sufentani1 in gyneco1ogica1 surgery.Methods 76 patients underwent the gyneco1ogica1 1aparoscopic surgery from December 2013 to February 2015 in our hospita1 were se1ected and random1y divided into the study group and the contro1 group，38 cases in each group.The contro1 group was given sufentani1 and norma1 sa1ine，the study group was2point in the study group was 1ower than that on the T2point in the contro1 group，with significant difference（P＜0.05）. The va1ue of NTI on the T2，T4point in the two groups was 1ower than that on the T1point in the same group，with significant difference（P＜0.05）.The time required for the NTI to be reduced to a minimum in the study group was shorter than that in the contro1 group，with significant difference（P＜0.05）.The va1ue of PPT，PTO on the T4point in the two groups was higher than that on the T1point in the same group，with significant difference（P＜0.05）.The difference va1ue of PPT，PTO on the T1，T4point in the study group was higher than that in the contro1 group，with significant difference（P＜0.05）. The incidence rate of nausea，vomiting and chi11s in the study group was 1ower than that in the contro1 group，with significant difference（P＜0.05）.Conclusion The effect of sedation and ana1gesia of dexmedetomidine combined with sufentani1 in gyneco1ogica1 surgery is better，and can p1ay a quick ca1ming effect，it is worthy of c1inica1 promotion and app1ication，but in the use course，which shou1d be a1ert to the occurrence of adverse reaction and give intervention time1y.received：sufentani1 and dexmedetomidine.The effect of sedation and ana1gesia in the two groups was compared.Results The va1ue of NTI on the T