新诊断早发2型糖尿病心脑血管疾病风险分析

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Abstract Objective To explore the clinical situation of blood fat，blood pressure，blood uric acid　（UA），high sensitive C reactive protein（hs-CRP），pancreatic islet function and insulin resistance of new diagnosed with early onset type 2 diabetes patients.M ethods 177 cases of new diagnosed with early onset type 2 diabeteswith complete clinical data in our hospital from January 2014 to December 2015 were selected as the research group，the early-onset group　（under 40 years old）was 63 cases，the control group　（aged 41-59 years old）was 114 cases.The clinical condition including blood lipid，blood pressure，hepatic and renal function，UA，hs-CRP，pancreatic islet function，and insulin resistance in the two groupswas compared，and whether there was a higher risk of cardiovascular and cerebrovascular risk in new diagnosed with early onset type 2 diabetes was discussed.Results The level of TC，TG，eGFR，UA，hs-CRP，DBP，HOMA-IR in the early-onset group was higher than that in the control group，and the level of the HDL-C in the early-onset group was lower than that in the control group，with significant difference　（P＜0.05）.There was no significant difference in the level of LDL-C，Cr，ALT，AST，SBP，fasting blood glucose，HbA1c，glycosylated albumin and HOMA-IS between the two groups （P＞0.05）.The age，waist circumference，BMIvalue in the early-onset group was higher than in the control group，with significant difference（P＜0.05）.Pearson correlation analysis showed that BMIwas positively correlated with TG，HOMA-IR and UA，and negatively correlated with age.TG was positively correlated with TC，hs-CRP，HOMA-IR，DBP，UA，BMI，and negatively correlated with HDL-C.Conclusion The clinical conditions about cardiaovascular risk of newly onset diabetes mellitus are more highly.There are the same important to correct the blood lipid disorder，treatment of hyperuricemia，improvement insulin resistance，antihypertension，as to antihyperglycaemia on new diagnosed with early onset type 2 diabetes to prevent vascular diseases.

Key words： Early onset diabetesmellitus Serum lipid Serum uric acid Blood pressure High sensitivity C reactive protein Insulin sensitivity index

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	Articles by authors
	LIN Shan-shan
	GUO Li-ming
	SHE Qi-mei
	YANG Xue-mei
	TIAN Ying-fang

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LIN Shan-shan,　GUO Li-ming,　SHE Qi-mei, et al. Risk analysis of cardiovascular and cerebrovascular disease in new diagnosed w ith early onset type 2 diabetes[J]. 中国当代医药, 2016, 23(20): 56-59.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I20/56

［1］	Wilmot E，Idris I.Early onset type 2 diabetes：risk factors，clinicalimpactandmanagement［J］.TherAdvChronic Dis，2014，5（6）234-244.
［2］	Levey　AS，Bosch　JP，Lewis JB，et al.A　more　accurate method to estimate glomerular filtration rate from serum creatinine：anew prediction equation［J］.Ann Intern Med，1999，130（6）：461-470.
［3］	王志会，王临虹，李镒冲，等.2010年中国60岁以上居民高血压和糖尿病及血脂异常状况调查［J］.中华预防医学杂志，2012，46（10）：922-926.
［4］	Cubbin C，Sundquist K，Ahlen H，et al.Neighborhood deprivation and cardiovascular disease risk factor：protective and harmful effect［J］.Scand JPublic Health，2006，34（3）：228-237.
［5］	Canto JG，Kiefe CI，Rogers WJ，et al.Number of coronary heart disease risk factors and mortality in patientswith first myocardial infarction［J］.JAMA，2011，306（19）：2120-2127.
［6］	Shepherd J，Blauw GJ，Murphy MB，et al.Pravastatin in elderly individuals at risk of vascular disease（PROSPER）：a randomized controlled trial［J］.Lancet，2002，360（9346）：1623-1630.
［7］	郑宏，张丽莉，李艳华.早发冠心病临床危险因素分析及其与预后的相关性探讨［J］.中国卫生统计，2013，30（3）：382-384.
［8］	Yang Q，Köttgen A，Dehghan A，et al.Multiple genetic lociinfluence serum urate levels and their relationship with gout and cardiovascular disease risk factors［J］.Circ Cardiovasc Genet，2010，3（6）：523-530.
［9］	秦绍森.高尿酸血症与脑卒中［J］.中国心血管杂志，2010，15 （6）：432-433.
［11］	林玉晶，高洪伟.C反应蛋白对糖尿病和非糖尿病的急性心肌梗死患者院内死亡的预测价值［J］.中国糖尿病杂志，2008，16（12）：763-764.
［10］	Kirbis S，Breskvar UD，Sabovic M，et al.inflammation markers in patients with coronary artery disease-comparison of intracoronary and systemic levels［J］.Wien KlinWochenschr，2010，122（2）：31-34.
［12］	Keskin O，Ulusoy RE，Kalemoglu M，et al.White blood cell count and C-reactive protein predict short-term prognosis in acute myocardial infarction［J］.J Int Med Res，2004，32 （6）：646-654.
［13］	董平栓，张薇.纤维蛋白原、高敏C反应蛋白与冠心病相关性分析［J］.陕西医学杂志，2009，38（3）：326-327.
［14］	Ridker PM，Danielson E，Fonseca FA，et al.Rosuvastatin to prevent vascular event in men and women with elevated C-reactive protein［J］.N Engl JMed，2008，359（21）：2195-2207.
［15］	高阅春，李全，何继强，等.超敏C反应蛋白水平与冠心病严重程度及预后的相关性研究［J］.中国全科医学，2012，15（8）：840-843.
［16］	何平，谢贤和，丁毅鹏，等.高敏C反应蛋白、脂蛋白a、血尿酸与冠状动脉病变程度的相关性［J］.中华医学杂志，2010，90（28）：1989-1991.
［17］	刘丽华.不同类型冠心病患者血清超敏C反应蛋白水平差异的研究［J］.中国心血管研究，2013，11（2）：95-96.
［18］	Lewington S，Clarke R，Qizilbash N，et al.Age-specific relevance of usual blood pressure to vascular mortality：a meta-analysis of individual data for onemillion adults in 61 prospective studies［J］.Lancet，2002，360（9349）：1903-1913.
［19］	中国高血压防治指南修订委员会.中国高血压防治指南2010［J］.中华心血管病杂志，2011，39（7）：579-615.
［22］	Brouwer BG，Visseren FL，Stolk RP，et al.Abdominal fat and risk of coronary heart disease in patientswith peripheral arterial disease［J］.Obesity（Silver Spring），2007，15（6）：1623-1630.
［20］	Park K，Lee DH，Erickso DJ，et al.association of long-term change in waist circumference with insulin resistance［J］. Obesity，2010，18（2）：370-376.
［21］	刘秀荣，李俊娟，王丽晔，等.腰围水平与糖尿病前期空腹血糖受损发病风险关系的研究［J］.中华流行病学杂志，2013，34（9）：884-887.