|
|
|
| Effect observation of drug combination de-escalation in the treatment of acute attack of wheezing in infants |
| CHEN Ai-qing ZHANG Jun-ling |
| Department of Pediatrics,the Second Community Health Service Center,Guanzhuang,Chaoyang District,Beijing 100070,China |
|
|
|
|
Abstract ObjectiveTo observe the clinical effect of drug combination de-escalation in the treatment of acute attack of wheezing in infants.MethodsFrom February 2015 to February 2017,103 infants with acute attack of wheezing in outpatient department of pediatrics in our center were selected as research objects.They were randomly divided into two groups.The comprehensive treatment was applied in both groups.In the observation group(n=52),de-escalation therapy was used,0.5mg/(kg·d)Prednisone for oral administration for 3 d,Salbutamol Sulfate solution for aerosol inhalation as required(2.5 mg each time),Ipratropium Bromide solution(125 μg each time for 7 d),and oral administration of 4 mg/d Montelukast for 14 d.In the control group (n=51),common treatments in clinic were used,like aerosol inhalation of Budesonide Suspension combined with or Inhalation of Salbutamol solution and Ipratropium Bromide solution as required to the stable period (2 weeks).The scores of symptoms and signs at different time points in the two groups were evaluated.The improvement of symptoms and signs 2 h,3 d,5 d,7 d after medication,disappearing time,and recurrent frequency of wheezing within one month follow up were observed.ResultsIn the observation group,the scores of improving wheezing,cough,and wheezing rale were higher than those in the control group (P<0.05).The disappearing time of these symptoms and signs was shorter compared with that in the control group(P<0.05).The recurrent frequency in the observation group within one month follow up was significantly lower than that in the control group,the difference was statistically significant(P<0.05).There was no drug adverse reaction in the two groups.ConclusionDrug combination de-escalation in the treatment of acute attack of wheezing in infants is remarkable on effect,safe and reliable.
|
|
|
|
|
|
| [1] |
申昆玲，尚云晓.儿科呼吸系统疾病诊疗常规[M].北京：人民卫生出版社，2015：29-30.
|
| [2] |
赵梦雅，刘传合.年幼儿童哮喘诊断的临床现状与研究进展[J].中国医刊，2016，51（11）：3-4.
|
| [3] |
江载芳，申昆玲，沈颖.诸福棠实用儿科学[M].8版.北京：人民卫生出版社，2015：1245-1248.
|
| [4] |
中华医学会儿科学分会呼吸组.《中华儿科杂志》编辑委员会.儿童支气管哮喘诊断与防治指南[J].中华儿科杂志，2008，46（10）：745-753.
|
| [5] |
鲍一笑，包军.婴幼儿喘息联合治疗方案[J].中国实用儿科杂志.2014，29（6）：411.
|
| [6] |
康小会，刘艳霞，陈再厉，等.布地奈德雾化吸入治疗儿童哮喘急性发作的疗效观察[J].中国实用儿科杂志，2002，17（1）：40-41.
|
| [7] |
周小建.雾化吸入支气管舒张剂合理应用[J].中国实用儿科杂志，2016，31（12）：891-893.
|
| [8] |
刘恩梅，黄海霞.儿科糖皮质激素的全身合理应用[J].中国实用儿科杂志，2012，27（11）：803-805.
|
| [9] |
Smith M ，Iaippaia SMSI，Rowe BH，et al.Corticosteroids for hospitalized children wich acute asthma[J].Cochrane Datahase Syst Rev，2003，1：CD002886
|
| [10] |
嵆若旭，李京阳，田野，等.短程小剂量口服激素在婴幼儿喘息急性期联合降价梯治疗方案中的作用研究[J].儿科药学杂志，2014，20（3）：11-12.
|
| [11] |
陈志敏，刘金玲.雾化吸入激素临床应用注意点[J].中国实用儿科杂志，2016，31（12）：887-889.
|
| [12] |
高苗苗，林芊，鲍一笑.联合降阶梯方案治疗婴幼儿喘息疗效及安全性研究[J].中国实用儿科杂志，2012，3（3）：202-205.
|
| [13] |
中华医学会儿科学分会呼吸组.白三烯受体拮抗剂在儿童常见呼吸系统疾病中的临床应用专家共识[J].中华实用儿科临床杂志，2016，31（13）：973-975.
|
| [14] |
杜启鹏，骆丹，叶茂清，等.联合降阶梯疗法治疗婴幼儿喘息的疗效观察[J].中国当代医药，2012，23（16）：85-86.
|
| [15] |
梁亮，黄丽意，陈婷女.降阶梯方案治疗门诊婴幼儿喘息临床效果观察[J].中国实用医药，2017，12（7）：122-124.
|
|
|
|
