苯磺酸氨氯地平和苯磺酸左旋氨氯地平治疗高血压的效果比较

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Abstract Objective To compare the effect of Amlodipine Besylate and Levamlodipine Besylate in the treatment of hypertension. Methods From January 2018 to May 2019,80 cases of patients with hypertension treated in our hospital were selected as subjects,they were divided into two groups according to the random number table method,40 cases in each group.The control group was given Amlodipine Besylate,while the observation group was given Levamlodipine Besylate.The clinical efficacy,blood pressure level,blood pressure variability,vascular endothelial function and total incidence of adverse reactions were compared. Results The total clinical effective rate of the observation group was higher than that of the control group,the difference was statistically significant (P<0.05).After treatment,the systolic blood pressure,diastolic blood pressure,morning peak of blood pressure,standard deviation of systolic blood pressure and systolic blood pressure variation index in the observation group were lower than those in the control group,the differences were statistically significant (P<0.05).After treatment,the level of nitric oxide in the observation group was lower than that in the control group,and the level of endothelin-1 in the observation group was higher than that in the control group,the differences were statistically significant (P<0.05).The total incidence of adverse reactions was compared between the two groups,the difference was not statistically significant (P>0.05).Conclusion Levamlodipine Besylate is superior to Amlodipine Besylate in the treatment of hypertension.The incidence of adverse reactions between Levamlodipine Besylate and Amlodipine Besylate is similar,and both have good medication safety.

Key words： Hypertension Amlodipine Besylate Levamlodipine Besylate Blood pressure Adverse reactions

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WANG Yun. Effect comparison between Amlodipine Besylate and Levamlodipine Besylate in the treatment of hypertension[J]. 中国当代医药, 2020, 27(21): 130-133.

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https://dangdaiyiyao.com/EN/ OR https://dangdaiyiyao.com/EN/Y2020/V27/I21/130

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