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| Clinical effect comparison of the Oxycodone Hydrochloride Sustained-release Tablets and Tramadol Hydrochloride Sustained-release Tablets in the treatment of moderate cancer pain |
| CHEN Cai-xia |
| Department of Clinical Pharmacy,Maoming Traditional Chinese Medicine Hospital,Guangdong Province,Maoming 525000,China |
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Abstract Objective To compare the clinical effect of Oxycodone Hydrochloride Sustained-release Tablets and Tramadol Hydrochloride Sustained-release Tablets in the treatment of moderate cancer pain. Methods From January 2014 to December 2018,100 patients with moderate cancer pain were selected as subjects and randomly divided into control group (n=50) and study group (n=50).The patients in the control group were treated with Tramadol Hydrochloride Sustained-release Tablets,and the patients in the study group were treated with Oxycodone Hydrochloride Sustained-release Tablets.The analgesic effect,quality of life scores before and after treatment and adverse reactions were compared between the two groups. Results The total effective rate of analgesia in the study group was 96.00%,which was higher than that in the control group (82.00%),the difference was statistically significant (P<0.05).The incidence rates of constipation,nausea,dizziness,lethargy and dysuria in the study group were 14.00%,16.00%,2.00%,6.00% and 2.00%,respectively,which were not significantly different from those in the control group (16.00%,14.00%,8.00%,4.00%,P>0.05).Before treatment,the appetite score of the study group was (1.75±0.55) points,mental state score of the study group was (1.65±0.70) points,sleep score of the study group was (1.80±0.65) points and daily living ability score of the study group was (1.95±0.70) points,compared with the control group [(1.70±0.60),(1.60±0.75),(1.85±0.60),(1.90±0.75) points],there were no significant differences between the two groups (P>0.05).The scores of quality of life after treatment in the two groups were higher than those before treatment,and the differences were statistically significant (P<0.05).After treatment,the appetite score of the study group was (3.80±0.35) points,mental state score of the study group was (4.25±0.60) points,sleep score of the study group was (4.10±0.70) points and daily living ability score of the study group was (3.15±0.60) points,compared with the control group [(3.65±0.40),(4.15±0.55),(3.95±0.85),(3.05±0.45) points],there were no significant differences between the two groups (P>0.05).Conclusion The clinical effect of Oxycodone Hydrochloride Sustained-release Tablets in the treatment of moderate cancer pain is accurate,which can effectively improve the quality of life after treatment and improve the clinical efficacy,and the incidence of adverse reactions is not increased,so it has important clinical application value.
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| [1] |
王启盛，吕亚莉，徐辉，等.盐酸羟考酮缓释片弱化二阶梯治疗的疗效和安全性研究[J].中国药房，2014，25（42）：3985-3987.
|
| [2] |
凌丽芬.盐酸羟考酮缓释片治疗晚期癌症疼痛的价值分析[J].临床合理用药杂志，2018，11（35）：64-65.
|
| [3] |
王梓丞，唐淑洁，张佳琦，等.盐酸羟考酮缓释片弱化二阶梯治疗用于癌性疼痛的疗效观察[J].中国医院用药评价与分析，2019，19（2）：158-160.
|
| [4] |
朱娴雅，徐秋萍，荣跃，等.盐酸羟考酮缓释片治疗中重度癌痛40 例的临床观察[J].中国实用医药，2018，13（29）：4-5.
|
| [5] |
胡夕春，王杰军，常建华，等.癌症疼痛诊疗上海专家共识（2017年版）[J].中国癌症杂志，2017，27（4）：312-320.
|
| [6] |
尹海庆.盐酸羟考酮缓释片与盐酸曲马多缓释片治疗中度癌痛疗效比较[J].肿瘤基础与临床，2017，30（5）：421-423.
|
| [7] |
胡成杰，方海树，程慧勇.盐酸羟考酮缓释片弱化二阶梯治疗的临床研究[J].当代医学，2018，24（27）：98-100.
|
| [8] |
刘玉华.羟考酮与吗啡片用于中度癌症疼痛患者治疗效果比较[J].中南医学科学杂志，2017，45（4）：374-377.
|
| [9] |
杨洋，吴夏慧，罗毅.盐酸羟考酮缓释片与硫酸吗啡缓释片治疗老年患者中重度癌痛的效果和安全性比较[J].中国医药，2018，13（5）：725-728.
|
| [10] |
陈梦婕，钱素英，诸静文，等.盐酸羟考酮缓释片治疗中度癌痛的疗效和安全性分析[J].现代实用医学，2016，28（11）：1469-1470.
|
| [11] |
崔剑，陈建平，郭芳，等.盐酸羟考酮缓释片在中重度成人癌痛门诊治疗中的疗效及安全性[J].山西医科大学学报，2018，49（3）：297-301.
|
| [12] |
林小平，吴文雪，吴如容，等.盐酸羟考酮缓释片联合吗啡即释片治疗晚期癌痛患者的观察和护理[J].浙江医学，2018，40（10）：1136-1137，1146.
|
| [13] |
郭珺，吕静，刘波，等.中重度癌痛盐酸羟考酮缓释片治疗剂量调整临床研究[J].中华肿瘤防治杂志，2017，24（18）：1319-1322.
|
| [14] |
杨婧，裴文仲，杨建东，等.羟考酮与曲马多对老年中度癌痛患者初始治疗效果的比较[J].癌症进展，2019，17（6）：697-700，703.
|
| [15] |
童刚领，吴烜，靳枫，等.盐酸羟考酮缓释片联合即释吗啡片用于中重度癌痛患者滴定的疗效[J].现代肿瘤医学，2016，24（20）：3267-3269.
|
| [16] |
陈思现，李汶珊.盐酸羟考酮缓释片与硫酸吗啡缓释片治疗阿片未耐受患者中、重度癌痛的效果比较[J].广东医学，2016，37（Z2）：206-208.
|
|
|
|
