摘要目的探讨吸入性糖皮质激素对稳定期慢性阻塞性肺疾病（COPD）的治疗效果。方法选取2016年3月～2017年3月在我院接受治疗的60例稳定期COPD患者进行研究，按照治疗方式分为观察组和对照组，每组30例。对照组予以常规方式治疗，观察组予以吸入性糖皮质激素治疗，治疗后1个月，对两组患者治疗前后的第一秒用力呼气容积（FEV1）、用力肺活量（FVC）、6 min 步行距离（6-MWD）、肿瘤坏死因子（TNF-α）、白介素-8（IL-8）、呼吸困难评分、生活质量评分、COPD发作次数、体质指数 （BMI）进行比较分析。结果观察组患者FEV1、FVC、6-MWD、BMI以及生活质量评分优于对照组，TNF-α、IL-8、呼吸困难评分、COPD发作次数较对照组低，差异有统计学意义（P＜0.05）。结论吸入性糖皮质激素治疗稳定期COPD疗效显著，安全性较高，可有效改善患者的肺功能状况，减少COPD发作次数，减轻呼吸困难等症状，进而不断提高患者的生活质量，值得临床推广应用。
Abstract：ObjectiveTo investigate the therapeutic effect of inhaled Glucocorticoid on stable COPD (chronic obstructive pulmonary disease).Methods60 patients with stable COPD who treated in our hospital from March 2016 to March 2017 were selected.All patients were divided into observation group and control group according to the treatment.methods,30 cases in each group.The control group was treated with routine treatment.The levels of FEV1,FVC,6-min walking distance （6-MWD）,TNF-α (TNF-α),IL-8,dyspnea score,quality of life score,the number of slow-onset pulmonary attack,BMI were measured one month after treatment.ResultsThe scores of FEV1,FVC,6-MWD,BMI and quality of life in the observation group were better than those in the control group,TNF-α,IL-8,dyspnea score and the number of slow-onset pulmonary episodes were lower than those in the control group,difference s were statistically significant(P＜0.05).ConclusionInhaled glucocorticoid treatment is effective in the treatment of stable COPD,and the safety is high.It can improve the pulmonary function of the patients,reduce the number of COPD attacks,reduce the symptoms of dyspnea,and thus continuously improve the quality of life of patients,worthy of clinical application.
Festic E，Scanlon PD.Incident pneumonia and mortality in patients with chronic obstructive pulmonary disease.A double effect of inhaled corticosteroids?[J].Am J Respir Crit Care Med，2015， 191（2）：141-148.
[15]
Martinez FJ，Rabe KF，Sethi S，et al.Effect of Roflumilast andInhaledCorticosteroid/Long-Actingβ2-AgonistonChronic ObstructivePulmonaryDiseaseExacerbations（RE（2）SPOND）.A Randomized Clinical Trial[J].Am J Respir Crit Care Med，2016，194（5）：559-567.
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