气体信号传导分子与婴幼儿轻度轮状病毒性肠炎伴良性惊厥的关系研究

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摘要目的探讨一氧化氮（NO）、一氧化氮合酶（NOS）及硫化氢（H2S）水平的变化与婴幼儿轻度轮状病毒肠炎合并良性惊厥的关系。方法选取2015年9月～2017年4月在沈阳市儿童医院确诊为轻度轮状病毒性肠炎伴良性惊厥患儿50例为观察组，选取同期的单纯轻度轮状病毒肠炎患儿50例为对照组。观察两组患儿的临床特点、常规实验室检查、NO、NOS、H2S变化及观察组的惊厥特点。结果两组患儿临床特点、常规实验室检查及NO水平比较，差异无统计学意义（P＞0.05）。观察组的血清NOS水平显著高于对照组，血清H2S水平显著低于对照组，差异均有统计学意义（P＜0.01）。结论轻度轮状病毒肠炎伴良性惊厥的发生与NO水平无关，与NOS、H2S水平有关，提示可以通过血清中NOS和H2S水平变化预测轻度轮状病毒肠炎患儿良性惊厥的发生。

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	陈瑞丹
	李娜
	穆亚平
	王爽
	李论

关键词 ：轮状病毒性肠炎, 良性惊厥, 血清一氧化氮, 血清一氧化氮合酶, 血清硫化氢

Abstract：Objective To explore the relationship between the change of nitric oxide(NO),nitric oxide synthase(NOS)and hydrogen sulfide (H2S)level in infants with mild Rotavirus enteritis accompanied with benign convulsions.Methods A total of 50 children diagnosed as mild Rotavirus enteritis accompanied with benign convulsion in Shenyang Children′s Hospital from September 2015 to April 2017 were selected as the observation group in Shenyang Children′s Hospital,and 50 children with simple mild Rotavirus enteritis were selected as the control group at the same time.The clinical features,routine laboratory tests,and NO,NOS,H2S changes in children of the two groups and convulsion characteristics of the observation group were observed.Results There was no significant difference in clinical characteristics,routine laboratory examination and NO level between the two groups(P＞0.05).The serum NOS level of the observation group was significantly higher than that of the control group,and the serum H2S level was significantly lower than that of the control group(P＜0.01).Conclusion The occurrence of mild rotavirus enteritis with benign convulsion is independent of NO level,and is related to NOS and H2S level,and it suggests that the incidence of benign convulsions in children with mild Rotavirus enteritis can be predicted by changes in serum NOS and H2S level.

Key words： Rotavirus enteritis Benign convulsion Serum nitric oxide Serum nitric oxide synthase Serum hydrogen sulfide

通讯作者: 穆亚平（1960-），女，主任医师，教授，研究方向：儿内科

引用本文:

陈瑞丹;李娜;穆亚平;王爽;李论. 气体信号传导分子与婴幼儿轻度轮状病毒性肠炎伴良性惊厥的关系研究[J]. 中国当代医药, 2018, 25(25): 19-22.
CHEN Rui-dan;LI Na;MU Ya-ping; WANG Shuang;LI Lun. Relationship study of gas signal conducting molecules and mild Rotavirus enteritis accompanied with benign convulsions in infants. 中国当代医药, 2018, 25(25): 19-22.

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