血清铁调素水平在脑梗死首发患者中的表达及临床意义

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摘要目的探讨血清铁调素水平在脑梗死首发患者中的表达及临床意义。方法选取我院2017年10月～2019年8月脑梗死首发患者117 例为观察组，选取117 例健康体检者为对照组，检测发病后1、3、5、7、14 及28 d 两组血清铁调素含量的变化情况。观察组入院当天采用美国国立卫生研究院脑卒中量表（NIHSS）评估患者病情严重程度，分为轻型（n=42）、中型（n=41）、重型（n=34）三组；发病3 个月随访时采用改良Rankin 量表（mRS）评估患者神经功能恢复情况，分为预后好组（n=64）、预后差组（n=53）。比较观察组与对照组不同时间点血清铁调素水平动态变化。分析观察组血清铁调素水平与神经功能缺损程度及预后的关系。结果观察组发病后第1、3、5、7、14、28 d的血清铁调素水平均高于对照组，差异有统计学意义（P<0.05）。观察组的轻、中、重型血清铁调素水平高于对照组，中、重型血清铁调素水平均高于轻型，重型血清铁调素水平均高于中型，差异均有统计学意义（P<0.05）。观察组中预后良好患者发病后第1、3、5、7、14、28 d 的血清铁调素水平均低于预后差患者，差异有统计学意义（P<0.05）。结论脑梗死后神经功能缺损程度越重血清铁调素表达越高，预后越差血清铁调素表达越高，血清铁调素水平与脑梗死的发生、病情严重程度、预后密切相关。

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	孙玙
	何杏玲
	杨水泉

关键词 ：脑梗死, 血清铁调素, 表达, 临床意义

Abstract：Objective To explore the expression and clinical significance of serum ferritin level in patients with initial cerebral infarction. Methods A total of 117 patients with cerebral infarction from October 2017 to August 2019 were selected as the observation group and 117 healthy people as the control group.Serum samples were obtained on 1,3,5,7,14 d and 28 d to detect the levels of hepcidin,observation group were further divided into light group (n=42)，moderate group (n=41) and heavy group (n=34) according to their NIHSS scores.The modified Rankin scale (mRS) was evaluated at 3 months after cerebral infarction.According to the mRS scores,the patients were divided into good prognosis group (n=64) and poor prognosis group (n=53).The changes of serum ferritin level were compared between the observation group and the control group at different time points.The relationship between serum hepcidin level and neurological deficit and prognosis in the observation group was analyzed. Results The levels of serum ferritin in the observation group were higher than those in the control group on the 1,3,5,7,14 d and 28 d after the onset of the disease (P<0.05).The levels of light,moderate and heavy serum ferritin in the observation group were higher than those in the control group,and the levels of moderate and heavy serum ferritin were higher than those in the light group,the level of heavy serum ferritin was higher than that in the moderate group,and the differences were statistically significant (P<0.05).In the observation group,the levels of serum ferritin water on the 1,3,5,7,14 d and 28 d after the onset of the disease were lower than those of the patients with poor prognosis,the differences were statistically significant(P<0.05).Conclusion After cerebral infarction,the expression of serum ferritin increased,and the more serious the degree of neurological impairment,the worse the prognosis,the more obvious the expression,the level of serum ferritin is closely related to the occurrence,severity and prognosis of cerebral infarction.

Key words： Cerebral infarction Serum hepcidin Expression；Clinical significance

基金资助:广东省佛山市科技计划项目（2016AB001405）

引用本文:

孙玙；何杏玲；杨水泉. 血清铁调素水平在脑梗死首发患者中的表达及临床意义[J]. 中国当代医药, 2020, 27(21): 64-66.
SUN Yu； HE Xing-Ling； YANG Shui-quan. Expression and clinical significance of serum ferritin level in patients with initial cerebral infarction. 中国当代医药, 2020, 27(21): 64-66.

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https://dangdaiyiyao.com/CN/ 或 https://dangdaiyiyao.com/CN/Y2020/V27/I21/64

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