中性粒细胞与淋巴细胞比值、纤维蛋白原对卵巢囊肿蒂扭转疾病进展的预测价值

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摘要目的探讨中性粒细胞与淋巴细胞比值（NLR）、纤维蛋白原（FIB）对卵巢囊肿蒂扭转疾病进展的预测价值。方法回顾性分析2016年1月至2020年3月福建省妇幼保健院收治的因卵巢囊肿蒂扭转行手术治疗并经术中证实扭转的60 例非妊娠患者的临床资料，根据术后病理结果将其分为正常组（23 例）、充血组（18 例）和坏死组（19 例）。对三组患者的临床资料进行统计学分析，分别绘制正常组与充血组、坏死组与非坏死组比较的受试者工作特征（ROC）曲线，分析NLR、FIB 预测扭转附件充血、坏死的临床价值。结果充血组患者的NLR 水平高于正常组，差异有统计学意义（P＜0.05）；坏死组患者的FIB 水平高于非坏死组，差异有统计学意义（P＜0.05）。NLR、FIB 预测扭转附件充血、坏死的曲线下面积（AUC）分别为0.785、0.771，临界值分别为3.11、2.91 g/L，敏感度分别为88.9%、73.7%。结论 NLR、FIB 对于扭转附件的充血、坏死具有一定的预测价值。

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	施森森

关键词 ：卵巢囊肿蒂扭转, 中性粒细胞与淋巴细胞比值, 纤维蛋白原, 预测价值

Abstract：Objective To investigate the predictive value of neutrophil to lymphocyte ratio (NLR) and fibrinogen (FIB)in the disease progression of ovarian cyst torsion.Methods Clinical data of 60 non-pregnant patients who were preoperatively diagnosed with ovarian cyst tortion and confirmed on intraoperative findings from January 2016 to March 2020 in Fujian Provincial Maternity and Children′s Health Hospital were retrospectively analyzed and classified into the normal group (n=23), congestive group (n=18) and necrotic group (n=19) depending on the postoperative histopathological examinations.The clinical data of the three groups were statistically analyzed.The receiver operating characteristic(ROC) curves of the normal group and the hyperemic group, the necrotic group and the non-necrotic group were drawn respectively, and the clinical value of NLR and FIB in predicting torsion accessory hyperemia and necrosis was analyzed.Results The level of NLR in hyperemia group was higher than that in normal group, and the difference was statistically significant (P＜0.05).The level of FIB in the necrotic group was higher than that in the non-necrotic group, the difference was statistically significant (P＜0.05).The area under curve (AUC) predicted by NLR and FIB were 0.785 and 0.771, the critical value was 3.11 and 2.91 g/L, respectively, and the sensitivity was 88.9% and 73.7%, respectively.Conclusion The NLR and FIB have predictive value in tissular congestion and necrosis of adnexal torsion to some extent.

Key words： Cystic ovarian tumors torsion Neutrophil to lymphocyte ratio Fibrinogen Predictive value

作者简介: 施森森（1990-），女，汉族，福建福州人，硕士，研究方向：妇产科（妇科肿瘤）。

引用本文:

施森森. 中性粒细胞与淋巴细胞比值、纤维蛋白原对卵巢囊肿蒂扭转疾病进展的预测价值[J]. 中国当代医药, 2021, 28(29): 21-24转29.
SHI Sen-sen. Predictive value of neutrophil to lymphocyte ratio and fibrinogen in the disease progression of ovarian cyst torsion. 中国当代医药, 2021, 28(29): 21-24转29.

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