利多卡因联合葛根素输注预防中心静脉置管相关性血栓的效果

Abstract
Figure/Table
References (20)
Related Citation (15)

Download: PDF (0 KB) HTML (34 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To observe the effect of Lidocaine combined with Puerarin infusion on prevention of central venous catheterization-related thrombosis,and to provide the basis for clinical efficacy.Methods A total of 50 inpatient surgical patients from October 2019 to December 2019 in Affiliated Hospital of Jinggangshan University were selected as the study subjects,the patients were divided into the experimental group (25 cases) and the control group (25 cases)according to random number table method.The experimental group received target controlled infusion of 2% Lidocaine at 2 μg/mL and 500 mg Puerarin intravenous drip at the end of operation.The control group received target-controlled infusion of 0.9% normal saline at 2 μg/mL until the end of operation.D dimer levels,hemorheology index,peak venous blood flow velocity,and mean velocity were compared between the two groups.Results The D dimer level and hemorheology index in the experimental group were lower than those in the control group,the peak velocity and average velocity of venous blood flow in the experimental group were higher than those in the control group,the differences were statistically significant (P＜0.05).Conclusion Lidocaine combined with Puerarin can reduce early central venous catheterization-related thrombus.

Key words： Lidocaine Puerarin Central venous catheterization Thrombus

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	DENG Zhen-zhen
	LIU Shu
	ZHOU Jin-feng

Cite this article:

DENG Zhen-zhen,LIU Shu,ZHOU Jin-feng. Effect of Lidocaine combined with Puerarin infusion on prevention of central venous catheterization-related thrombus[J]. 中国当代医药, 2021, 28(4): 30-33.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I4/30

[12]	张秀婷，刘晓钰，李秋环.恶性血液病患者PICC 相关血栓形成危险因素分析[J].齐鲁护理杂志，2018，24（21）：94-97.
[2]	杨帆，刘庆春，陈巧珠.彩色多普勒超声对颈内静脉置管后附管血栓形成的诊断价值[J].岭南心血管病杂志，2015，21（4）：497-499.
[1]	Fletcher JJ，Stetler W，Wilson TJ，et al.The clinical signifi canoe of peripherally inserted central venous catheter-related deep vein thrombosis[J].Neurocrit Care，2011，15（3）：134-137.
[3]	Clements R，Churilov L.Exploratory analysis of factors as sociated with venous thrombo embolism in Victorian acute traumatic spinal cord injured patients[J].Spinal Cord，2017，55（1）：74-78.
[4]	Granziera S，Cohen AT.VTE primary prevention，includic surgical patients[J].Thromb Haemost，2015，113（6）：1216-1223.
[5]	Piegeler T，Votta-Velis EG，Bakhshi FR，et al.Endothelial barrier protection by local anesthetics：ropivacaine and lidocaine block tumor necrosis factor alpha-induced endothelial cell Src activation[J].Anesthesiology，2014，120（6）：1414-1428.
[6]	Koch CA.A Novel Approach for Preventing the Development of Persistent Vasospasms after Microsurgery for the Extremities：Intermittent Topical Lidocaine Application[J].J Reconstr Microsurg，2010，26（2）：79-85.
[7]	侯筱婷.葛根素对心脑血管疾病影响的研究进展[J].中西医结合心脑血管病杂志，2018，16（14）：2002-2004.
[8]	徐学燕，边春鸽.经外周穿刺中心静脉置管术相关性上肢深静脉血栓危险因素分析[J].中国现代医生，2020，58（4）：76-79，83.
[9]	廖珍.PICC 相关性血栓形成影响因素临床分析[J].现代诊断与治疗，2018，29（21）：3527-3529.
[10]	张伟伟，方云.血液肿瘤患者PICC 导管相关性血栓形成的危险因素分析[J].临床血液学杂志，2018，32（2）：197-200.
[11]	关晨阳，廖海涛，高文，等.肿瘤患者PICC 导管相关性血栓与凝血指标变化关系的研究[J].中国实用护理杂志，2018，34（11）：848-852.
[13]	Kearon C，Akl EA，Comerota AJ，et al.Antithrombotic therapy for VET disease：antithrombotic therapy and preventin of thrombosis，9thed：American College of Chest Physicians Evidence-Based Clinical Practice Guidelines[J].Chest，2012，141（2 Suppl）：e419s-e496s.
[14]	徐兆景.葛根素药理作用机制探讨及其临床应用.中国现代药物应用，2016，10（8）：256-257.
[15]	Hollmann MW，Herroeder S，Kurz KS，et al.Time-dependent inhibition of G protein-coupled receptor signaling by local anesthetics[J].Anesthesiology，2004，100（12）：852-860.
[16]	Wei Z.Research on the effect of puerarin on alleviating sports fatigue[J].Open Biomed Eng J，2015，13（9）：288-291.
[17]	李继峰，顾玉东，钟慈声.药物及吸烟对大鼠血管吻合口内皮细胞愈合的影响[J].上海医科大学学报，2013，27（5）：350-353.
[18]	宋琳琳，吴新明，解大建.急性等容性血液稀释与利多卡因把控输注对大鼠下腔静脉血栓形成的影响[J].临床麻醉学杂志，2011，24（2）：157-160.
[19]	Cooke ED，Bowcock SA，Lloyd，et al.Intravenous lignoccaine in prevention of deep venous throm bosis after elective hipsurgery[J].Lancet，1977，15：797-799.
[20]	朱士奎，王洪元，方保锋.利多卡因联合奥扎格雷钠、低分子肝素钙治疗短暂性脑缺血发作38例疗效观察[J].中国医药导刊，2011，13（4）：644-6445.