低蛋白血症对慢性心力衰竭预后的影响分析

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Abstract Objective To study of the effect of hypoproteinemia on the prognosis of patients with chronic heart failure.Methods 94 patients who diagnosed with chronic heart failure withⅡ-Ⅳgrade of cardiac function were selected from March 2013 to March 2015 of the Department of Cardiovascular Medicine in General Hospital of China Aviation,and patients were divided into the 3 groups according to the level of serum albumin:48 cases in normal group,28 cases in mild hypoproteinemia and 18 cases in moderate and severe hypoproteinemia.A prospective study was carried out for 2 years after routine treatment of heart failure.The data were collected.The effect of serum albumin level on rehospitalization rate,case fatality rate and related indexes of cardiac function in patients with chronic heart failure were analyzed.Results The rate of rehospitalization and case fatality rate in patients with chronic heart failure with hypoproteinemia was higher than that in the normal group,and the difference was statistically significant(P＜0.05).The rate of rehospitalization and mortality in patients with moderate and severe hypoproteinemia with chronic heart failure was higher than that in the mild hypoproteinemia group,and the difference was statistically significant(P＜0.05).After 2 years,the N terminal pro brain natriuretic peptide(NT-proBNP),left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDV)and 6 min walking distance in normal group were significantly improved compared with before treatment,and the difference was statistically significant(P＜0.05).After 2 years,the above indexes of the hypoproteinemia group were worse than those before treatment,and the difference was statistically significant(P＜0.05).The lower the albumin level,the worse the cardiac function index.Conclusion Patients with chronic heart failure and hypoproteinemia have a higher rate of rehospitalization and case fatality rate,and the lower the albumin level,the more serious the patient′s condition is and the worse the prognosis.

Key words： Chronic heart failure Hypoproteinemia Prognosis Rehospitalization rate Case fatality rate N terminal pro brain natriuretic peptide

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	LIU Qian
	WANG LI-zhong
	CHEN Meng-na

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LIU Qian,WANG LI-zhong,CHEN Meng-na. Analysis the effect of hypoproteinemia on the prognosis of chronic heart failure[J]. 中国当代医药, 2018, 25(19): 24-27.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I19/24

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