Study on the effects of metabolic syndrome during pregnancy on maternal and infantile lipid metabolism
LI Xiu-ming1 JI Jia-fen1▲ LIU Chang-yun1 ZHU Hai-ling2 ZHANG Qi1 ZHAI Yu-ping1 ZHENG Yang1
1.Department of Pediatric Teaching and Research,Weifang Medical University,Shandong Province,Weifang 261000,China;
2.Affiliated Hospital of Weifang Medical University,Shandong Province,Weifang 261000,China
AbstractObjectiveTo study the effects of metabolic syndrome during pregnancy on lipid metabolism in pregnant women and the effects on the early lipid metabolism in their offspring.MethodsA total of 40 pregnant women who were hospitalized and gave delivery in the department of obstetrics in the Affiliated Hospital of Weifang Medical University from May 2016 to May 2017 were selected.Among them,20 cases of the pregnant women with metabolic syndrome in pregnancy and 20 offsprings of theirs were assigned to the study groups.20 healthy pregnant women and their offsprings were assigned to the control groups.The levels of apolipoprotein E,adiponectinand leptin in the serum of pregnancy women were measured respectively.At the same time,the correlation analysis between the above three components in the umbilical cord serum of the offspring were carried out.ResultsApolipoprotein E was (490.15±90.76)ng/ml and leptin was(4.92±1.00)ng/ml in the pregnancy women in the study group.The Apolipoprotein was(576.95±83.37)ng/ml and leptin was (3.16±1.18)ng/ml in their offsprings,which were all higher than those in the control group for pregnant women,apolipoprotein E and leptin were(389.51±69.37)ng/ml and(3.83±0.52)ng/ml respectively,and for the offsprings,the apolipoprotein E and leptin were(400.38±57.25)ng/ml and(2.29±1.01)ng/ml respectively;adiponectin was(4.76±1.19)ng/ml in the pregnancy women in the study group,and adiponectin was(4.29±1.34)ng/ml in their offsprings,which were both lower than those in the control group(adiponectin was[7.63±2.77]ng/ml in the pregnant women,and the adiponectin was [6.32±1.97]ng/ml in the offsprings).The differences were statistically significant(P<0.05).ConclusionMetabolic syndrome during pregnancy leads to abnormal lipid metabolism in pregnant women and affects early lipid metabolism in the offsprings,which increases the risk of future metabolic syndrome in the offsprings.
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