|
|
|
| The efficacy and safety of Clopidogrel combined with Low Molecular Weight Heparin Calcium in the treatment of progressive ischemic stroke |
| FANG Ming |
| Department of Internal Neurology,the Third Hospital of Nanchang City in Jiangxi Province,Nanchang 330009,China |
|
|
|
|
Abstract ObjectiveTo investigate the efficacy and safety of Clopidogrel combined with Low Molecular Weight Heparin Calcium in the treatment of progressive ischemic stroke.Methods96 patients with progressive ischemic stroke who were treated in our hospital from March 2014 to December 2016 were selected and randomly divided into the observation group and the control group,each group had 48 cases.The control group was treated with Low Molecular Heparin Calcium,while the observation group was treated with Clopidogrel on the basis of the control group.And the curative effects,neurological deficit score(NIHSS)and the changes of plasma viscosity,fibrinogen,platelet aggregation rate and other hemodynamic parameters before and after treatment of the two groups were compared.Then the adverse reactions of the two groups were observed.ResultsThe total effective rate of the observation group was 93.75%,and it was significantly higher than that of the control group(79.17%),and the difference was statistically significant(P<0.05).NIHSS of the observation group was significantly lower than that of the control group after the treatment,and the difference was statistically significant(P<0.05).In terms of hemodynamics,the plasma viscosity,fibrinogen and platelet aggregation rate in the observation group were significantly lower than those in the control group,and the difference was statistically significant(P<0.05).there was no significant difference in the total incidence rate of adverse reactions between the two groups after treatment(P>0.05).ConclusionClopidogrel combined with Low Molecular Weight Heparin Calcium in the treatment of progressive ischemic stroke is effective and safe,and it has a higher application value in clinic.
|
|
|
|
|
|
| [1] |
刘刚.氯吡格雷联合低分子肝素钙治疗进展性缺血性脑卒中临床疗效观察[J].河北医学，2015，21（11）：1850-1853.
|
| [2] |
朱林，王治国，王树桢，等.低分子肝素钙联合氯吡格雷治疗进展性缺血性脑卒中的临床研究[J].广西医科大学学报，2016，33（2）：280-282.
|
| [3] |
肖青.氯吡格雷联合低分子肝素钙治疗短暂性脑缺血发作的临床疗效[J].现代仪器与医疗，2014，20（4）：75-77.
|
| [4] |
朱林，王治国，王树桢，等.低分子肝素钙联合氯吡格雷治疗进展性缺血性脑卒中的临床研究[J].广西医科大学学报，2016，33（2）：280-282.
|
| [5] |
钮佳丽，丁云龙.氯吡格雷防治缺血性脑卒中的争议与进展[J].医药导报，2015，34（12）：1614-1617.
|
| [6] |
李春光，彭英.进展性缺血性脑卒中[J].中华脑科疾病与康复杂志（电子版），2012，2（2）：87-91.
|
| [7] |
谢霞，张治中，马敏敏，等.缺血性脑卒中氯吡格雷抵抗的研究进展[J].内科急危重症杂志，2014，20（3）：145-147.
|
| [8] |
武燕，李敏，蔺洪翔，等.缺血性脑卒中抗血小板治疗的研究进展[J].中国全科医学，2015，18（23）：2865-2869.
|
| [9] |
李雪雁.低分子肝素钙联合血塞通治疗进展性缺血性脑卒中116例临床观察[J].世界中医药，2016，11（6）：2057-2057.
|
| [10] |
徐大飞，李凯，陈海波.氯吡格雷联合阿司匹林治疗进展性缺血性脑卒中的临床疗效和安全性[J].海南医学院学报，2014，20（9）：28-32.
|
| [11] |
张江，李凤云，王大力.进展性缺血性脑卒中相关危险因素分析[J].现代预防医学，2014，41（21）：3938-3940.
|
| [12] |
秦峰，蔡辉.急性缺血性卒中的药物治疗进展[J].疑难病杂志，2015，14（8）：870-876.
|
| [13] |
涂雪松.进展性缺血性脑卒中的影响因素[J].卒中与神经疾病，2014，21（3）：192.
|
| [14] |
张金华，董佳丽，眭晓月.皮下注射低分子肝素钙不良反应的观察与护理[J].中国实用护理杂志，2015，31（5）：107-108.
|
| [15] |
牛少辉，张丽华，简立国.氯吡格雷联合阿司匹林治疗急性心肌梗死的疗效观察[J].中国临床医学，2014，21（2）：151-153.
|
|
|
|
