无创-有创机械通气序贯治疗切换时机的临床研究

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Abstract Objective To explore the switching time of sequential with non-invasive and invasive mechanical ventilation.Methods A total of 80 cases with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) admitted to Zhongshan Hospital from January 2019 to May 2020 were selected as research objects and divided into two groups according to random number table method, with 40 cases in each group.The control group was treated with experience, while the observation group was treated with the switch point between invasive breathing and non-invasive breathing in the control window of lung infection.The levels of inflammation-related factors, pulmonary function, St.George′s respiratory questionnaire (SGRQ) scores before and after treatment and complications of the two groups were compared, the main complications included ventilator-associated pneumonia, pneumothorax and heart failure.Results The levels of tumor necrosis factor-α (TNF-α) and hypersensitive C-reactive protein (hs-CRP) in the observation group were lower than those in the control group after treatment, and the differences were statistically significant (P＜0.05).The levels of forced expiratory volume in one second (FEV1) and forced expiratory volume in one second／forced vital capacity (FEV1/FVC) in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05).The SGRQ scores of the two groups were lower than those at 48 h and 7 d after treatment before treatment, the SGRQ score of the observation group was lower than that of the control group, and the differences were statistically significant(P＜0.05).The total incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05).Conclusion The application of pulmonary infection control window as the switching point can effectively reduce the inflammatory response, improve respiratory function and reduce the complications incidence with noninvasive-invasive ventilator sequentially.

Key words： Non-invasive ventilator Invasive ventilator Mechanical ventilation Acute exacerbation of chronic obstructive pulmonary disease Switching opportunity

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	XU Jin-quan
	GANG Li
	ZHANG Xin-li

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XU Jin-quan,GANG Li,ZHANG Xin-li. Clinical study on the switching timing of sequential treatment of non-invasive and invasive mechanical ventilation[J]. 中国当代医药, 2021, 28(8): 66-69.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I8/66

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