Objective To explore the correlation of pepsinogen and gastrin-17 (G-17) with chronic renal failure (CRF).Mehtods A total of 100 patients with CRF who were admitted to Clifford Hospital from December 2019 to March 2020 were selected as the research subjects.According to chronickidney disease (CKD) stage,they were divided into group 1(33 cases),group 2 (34 cases) and group 3 (33 cases).Meanwhile,30 healthy people in the same period were selected as the control group.Serum Prothrombin Ⅰ(PGⅠ),serum Prothrombin Ⅱ(PGⅡ),G-17 and renal function were compared among different groups.The Pearson correlation was used to analyze the closeness between PGⅠ,PGⅡ,G-17 and serum creatimine (SCr) in CRF.Results The levels of PGⅠ,PGⅡand G-17 in group 1,2 and 3 were higher than those in the control group,the differences were statistically significant (P＜0.05).The level of PGⅡin group 3 was higher than that in group 1,the difference was statistically significant (P＜0.01).The levels of G-17 in group 2 and 3 were higher than that in group 1,the differences were statistically significant (P＜0.01).The level of G-17 in group 3 was higher than that in group 2,the difference was statistically significant (P＜0.01).The levels of SCr and urea nitrogen(BUN) in groups 1,2 and 3 were higher than those in control group,the differences were statistically significant (P＜0.05).BUN in group 3 was higher than that in group 1,the difference was statistically significant (P＜0.01).BUN in group 2 was higher than that in group 1,the difference was statistically significant (P＜0.05).Serum PGⅠ,PGⅡ,and G-17 levels positively correlated with SCr levels in CFR (P＜0.01).Conclusion Kidney damage may lead to elevated PGⅠ,PGⅡand G-17 levels,which has a certain degree of relation between them.The pepsinogen and gastrin are measurement indicators to reflect the gastric function,which can be used as the screening indicators of gastrointestinal symptoms in patients with chronic renal failure and guide the clinical judgment.