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| Efficacy and safety of Aspirin and Clopidogrel in the treatment of acute cerebral infarction |
| GUO Hong-yan |
| Department of Neurology,Iron and Coal General Hospital of Liaoning Health Industry Group,Liaoning Province,Tieling 112700,China |
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Abstract Objective To investigate the effect and adverse reactions of Aspirin combined with Clopidogrel in the treatment of acute cerebral infarction.Methods A total of 102 patients with acute cerebral infarction admitted to the Iron and Coal General Hospital of Liaoning Health Industry Group from December 2018 to January 2020 were selected as the research subjects.According to the random number table method,they were divided into observation group (51 cases)and control group (51 cases).The control group was treated with Aspirin while the observation group was treated with Aspirin and Clopidogrel.After treatment,the total effective rate,the National Institutes of Health Stroke Scale (NIHSS)score,the health status questionnaire(SF-36)scores,hemorheology indexes and adverse reactions were compared between the two groups.Results The total effective rate of observation group was higher than that of control group,the difference was statistically significant (P<0.05).There were no significant differences in NIHSS and SF-36 scores between the two groups before treatment (P>0.05).After treatment,the NIHSS scores of the two groups were lower than those before treatment,and the SF-36 scores were higher than those before treatment,the differences were statistically significant (P<0.05).The NIHSS score of the observation group after treatment was lower than that of the control group,and the SF-36 score was higher than that of the control group,and the differences were statistically significant (P<0.05).The red blood cell aggregation index of the observation group was lower than that of the control group,the plasma viscosity,the low shear viscosity of whole blood,the maximum platelet aggregation induced by arachidonic acid the rate of platelet aggregation (MARAA) and the maximum platelet aggregation rate (MARADP) induced by adenosine diphosphate were higher than those of the control group,and the differences were statistically significant (P<0.05).Comparison of total incidence of adverse reactions between two groups,the difference was not statistically significant (P>0.05).Conclusion The use of Aspirin combined with Clopidogrel in the treatment of patients with acute cerebral infarction can effectively improve blood circulation and nerve function,improve clinical symptoms,and contribute to the improvement of patients′ quality of life,which is of development value.
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| [1] |
林东.阿司匹林与氯吡格雷治疗急性脑梗死的临床研究[J].深圳中西医结合杂志，2018，28（15）：149-150.
|
| [2] |
吉廷鑫.阿司匹林与氯吡格雷联合治疗急性脑梗死的临床疗效分析[J].中国现代药物应用，2018，12（9）：101-102.
|
| [3] |
韩长鸣，段前梅，竺峰.阿司匹林与氯吡格雷联合治疗急性脑梗死的疗效分析[J].齐齐哈尔医学院学报，2019，40（8）：961-962.
|
| [4] |
邹纯才，鄢海燕，王莉丽，等.基于网络药理学分析瓜蒌阿司匹林配伍抗血小板聚集和抗血栓的作用机制研究[J].中国中药杂志，2019，44（8）：1654-1659.
|
| [5] |
冼文川，林力峰，林智君.拜阿司匹林联合氯吡格雷治疗急性轻型脑梗死的临床疗效及不良反应分析[J].中国医药科学，2020，10（1）：91-93.
|
| [6] |
冯真，刘鹏.阿司匹林联合氯吡格雷对急性脑梗死患者血小板活化及神经功能的影响[J].中国医院用药评价与分析，2018，18（6）：803-804，807.
|
| [7] |
焦俊杰，孙亚红，马凤仪.氢氯吡格雷联合拜阿司匹林治疗急性脑梗死的效果评估与分析[J].中国现代药物应用，2017，11（6）：41-43.
|
| [8] |
刘洋，姜盼盼，杨佳，等.阿司匹林联合氯吡格雷治疗急性脑梗死预后预测量表的建立及其效果的初步评价[J].中华神经医学杂志，2019，18（11）：1136-1141.
|
| [9] |
王根强，龙登毅，贝宁，等.瑞舒伐他汀钙胶囊联合阿司匹林肠溶片和氯吡格雷片治疗老年急性脑梗死的临床研究[J].中国临床药理学杂志，2018，34（15）：1755-1757，1761.
|
| [10] |
王挺刚，桂树华，狄美琪，等.阿司匹林、氯吡格雷联合疏血通注射液治疗急性脑梗死的临床效果及对血液流变学的影响[J].临床误诊误治，2019，32（1）：60-63.
|
| [11] |
高娟.阿司匹林联合氯吡格雷治疗急性脑梗死对患者认知功能的影响[J].解放军预防医学杂志，2018，36（9）：113-115，128.
|
| [12] |
龙章玲，胡晓.阿司匹林和氯吡格雷在急性脑梗死中的应用进展[J].中国医药，2019，14（8）：1262-1265.
|
| [13] |
侯晓玲，李雅.氯吡格雷联合阿司匹林治疗急性心肌梗死对临床疗效心功能及预后观察[J].山西医药杂志，2019，48（10）：47-49.
|
| [14] |
朱葛敏，闫俊，燕玉娥.阿司匹林联合氯吡格雷治疗急性脑梗死并2型糖尿病的临床观察[J].国际神经病学神经外科学杂志，2018，45（5）：481-485.
|
| [15] |
刘丽丹，田新玮，刘文萍，等.拜阿司匹林联合氯吡格雷在急性脑梗塞中的应用对CD-63、CD62P 和PAC-1 以及炎性因子、血小板聚集功能的影响[J].中国卫生检验杂志，2018，28（3）：332-334.
|
|
|
|
