S100A8/A9和S100A4在外阴硬化性苔藓中的表达及意义

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Abstract Objective To detect the expression of S100A8/A9 and S100A4 in vulvar sclerosing mosses,and to explore the relationships between S100A8/A9,S100A4 and vulvar sclerosing mosses.Methods Thirty surgical specimens were collected from the Department of Gynecology of the First Affiliated Hospital of China Medical University from January 2008 to January 2018 in patients with vulvar sclerosing mosses.The normal vulva skin samples of 10 patients who needed vaginal surgery such as uterine prolapse from January 2013 to January 2018 were selected from the Gynecological Ward of the First Affiliated Hospital of China Medical University.The samples were detected by SABC immunohistochemistry.The expression of S100A8/A9 and S100A4 were analyzed.Results In normal skin of vulva,S100A8/A9 positive cells were mostly located in basal cell layer,and the optical density of S100A8/A9 positive cells was 0.7946±0.1369.However,in vulvar sclerosing mosses,S100A8/A9 positive cells were mostly located near the whole layer of epidermis,and the optical density of S100A8/A9 positive cells was 1.6206±0.4312.The optical density of S100A8/A9 positive cells in vulvar sclerosing mosses was higher than that in normal vulva skin,and the difference was statistically significant (P<0.05).In normal skin of vulva,S100A4 positive cells were mostly located in basal cell layer,and a small amount of stromal cells were positively expressed in dermis.The optical density of S100A4 positive cells was 0.3020±0.1266.However,in mosses sclerosing vulva,S100A4 positive cells were still located in the basal layer and were negatively expressed in the interstitium.The optical density of S100A4 positive cells was 0.3583±0.1575.There was no significant difference in the optical density of S100A4 positive cells between mosses sclerosing vulva and normal vulva skin samples (P>0.05).Conclusion S100A8/A9 take a part in the pathological process of vulvar sclerosing mosses,however S100A4 may not have definite correlation with the pathological process of vulvar sclerosing mosses.

Key words： S100A8/A9 S100A4 Vulvar sclerosing mosses Immunohistochemistry

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	CHEN Xiao-dan
	MENG Fei
	WU Xin

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CHEN Xiao-dan,MENG Fei,WU Xin. Expression and significance of S100A8/A9 and S100A4 in vulvar sclerosing mosses[J]. 中国当代医药, 2021, 28(4): 119-121转125.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I4/119

[3]	Yu XY，Wu X.Clinical analysis of 109 cases of vulvar squamous cell carcinoma[J].J Cancer Res Clin，2014，26（4）：24-242.
[1]	Kinoshita R，Sakaguchi M，Kondo E，et al.Development of a novel S100A8/A9 neutralizing monoclonal antibody for suppression of cancer metastasis[J].Cancer Sci，2018，109：924.
[2]	Milianciesielska K，Chmura L，Dyduch G，et al.Intraepidermal nerve fiber density in vulvar lichen sclerosus and normal vulvar tissues[J].J Physiol Pharmacol，2017，68（3）：453-458.
[4]	Bleeker MC，Visser PJ，Overbeek LI，et al.Lichen sclerosus：incidence and risk of vulvar squamous cell car-cinoma[J].Cancer Epidem Biomar，2016，25（8）：1224-1230.
[5]	Tian T，Li X，Zhen H，et al.S100A7 promotes the migration，invasion and metastasis of human cervical cancer cells through epithelial-mesenchymal transition[J].Oncotarget，2017，8（15）：24 964-24 977.
[6]	Liu YF，He XS，Xu G，et al.Relationship of the S100A2 protein and differentitation of gastric carcinoma[J].Med Ed，2005，33（1）：1-3.
[7]	Heizmann CW，Ackermann GE，Galichet A，et al.Pathologies involving the S100 proteins and RAGE[J].Subcell Biochem，2007，45：93-138.
[8]	Donato R.S100：a multigenic family of calcium-modulated proteins of the EF-hand type with intracelluar and extracelluar function roles[J].Int J Biochem Cell B，2001，33（7）：637-668.
[9]	Yui S，Nakatani Y，Mikam LM.Calprotectin（S100A8/S100A9），an inflammatory protein complex from neutrophils with a broad apoptosis-inducing activity[J].Biol Pharm Bul，2003，26（6）：753-760.
[10]	Asghari H，Chegini KG，Amini A，et al.Effect of poly and monounsaturated fatty acids on stability and structure of recombinant S100A8/A9[J].Int J Biol Macromol，2016，84：35-42.
[11]	Kovacic MA，Beleslin C，et al.S100A8/9 Activation of MAPK Pathway Is Supported By Its Receptors Rage and TLR4 In Polycythemia Vera[J].Haematologica，2017，102：540.
[12]	Ambartsumian N，J，Grigorian M.The Multifaceted S100A4 Protein in Cancer and Inflammation[J].Methods Mol Biol，2019，1929：339-365.
[13]	Mathias D，Dennis K，Wolfgang W，et al.S100A4 in cancer metastasis：WNT signaling-driven interventions for metastasis restriction[J].Cancers，2016，8（6）：59.
[14]	赵云霞，陈雪，刘畅，等.S100A7 和S100A4 在外阴鳞癌与外阴硬化性苔藓中的表达及意义[J].现代肿瘤医学，2018，26（10）：1573-1576.
[15]	Chen L，Li J，Zhang J，et al.S100A4 promotes liver fibrosis via activation of hepatic stellate cells[J].J Hepatol，2015，62（1）：156.