活动性巨细胞病毒感染DNA载量与2型糖尿病患者T淋巴细胞亚群的关系

Abstract
Figure/Table
References (16)
Related Citation (15)

Download: PDF (0 KB) HTML (35 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the relationship between DNA load of active cytomegalovirus infection and T lymphocyte subsets in patients with type 2 diabetes mellitus (T2DM). Methods The clinical data of 80 patients with T2DM treated in Pingxiang People's Hospital between October 2019 and May 2020 were retrospectively analyzed. According to the active cytomegalovirus infection status, the patients were divided into observation group (positive cytomegalovirus infection, viral DNA load＞500 copies/ml, n=18) and control group (negative cytomegalovirus infection, viral DNA load≤500 copies/ml, n=62). The T lymphocyte subsets (CD4+, CD8+, CD4+/CD8+) and pancreatic islet function (fasting Cpeptide [Fins], fasting 2 h C-peptide [F2CP]) were compared between the two groups. Pearson correlation analysis was used to analyze the correlation between DNA load of active cytomegalovirus infection and levels of T lymphocyte subsets and pancreatic islet function. Results The level of CD4+cells and CD4+/CD8+in observation group were significantly lower than those in control group, while the level of CD8+ cells was higher than that in control group, the differences were statistically significcant (P＜0.05). The levels of FCP and F2CP were lower in observation group than those in control group, the differences were statistically significcant (P＜0.05). The DNA load of cytomegalovirus infection was negatively correlated with CD4+, CD4+/CD8+, Fins and ISI, and was positively correlated with CD8+level (P＜0.05). Conclusion The DNA load of active cytomegalovirus infection is closely related to the T lymphocyte subsets of patients with T2DM. The more active cytomegalovirus in the body of patients, the greater the degree of body's immune imbalance and the more severe the islet function damage. It is necessary to take corresponding treatment methods to improve the cytomegalovirus infection status.

Key words： Cytomegalovirus DNA load Type 2 diabetes mellitus T lymphocyte subsets

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	CAI Li-juan
	REN Mei
	LIU Jian-rong
	PAN Xing

Cite this article:

CAI Li-juan,REN Mei,LIU Jian-rong, et al. Relationship between DNA load of active cytomegalovirus infection and T lymphocyte subsets in patients with type 2 diabetes mellitus[J]. 中国当代医药, 2021, 28(30): 161-163.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I30/161

[3]	方勇明，章秋霞.调节性T 细胞亚群在2 型糖尿病患者中的分布异常研究[J].中国卫生检验杂志，2020，30（20）：2507-2509.
[4]	张君，江晓静.巨细胞病毒感染与糖尿病发病机制研究进展[J].中国感染控制杂志，2016，15（1）：68-72.
[5]	周洁，马莉，杨梅，等.2 型糖尿病及并发症患者相关细胞检测的意义[J].贵州医药，2016，40（12）：1261-1262.
[6]	王建，曹伟锋，毛月燕，等.流式细胞术检测人巨细胞病毒活动性感染检测方法的建立及检测效果评价[J].病毒学报，2017，33（3）：450-454.
[7]	齐宗利，张瑜庆，胡军.病毒感染与1 型糖尿病[J].生命的化学，2016，36（1）：45-49.
[1]	单志明，胡建华，李敏环，等.人巨细胞病毒感染对多种病毒感染的影响[J].中华检验医学杂志，2012，35（1）：59-61.
[2]	王诗钰，李国超，陈柳，等.CD4+T 细胞亚群与2 型糖尿病发生发展的相关性研究[J].中国糖尿病杂志，2018，26（10）：839-843.
[8]	脱厚珍，车晶晶，刘磊，等.HCMV 感染致培养脐静脉内皮细胞活化和氧化应激的作用[J].中华实验和临床病毒学杂志，2017，31（4）：298-301.
[9]	钟峰，赵俊，张业婷，等.定量检测HCMV pp67 mRNA 快速诊断人巨细胞病毒活动性感染[J].安徽医科大学学报，2016，51（3）：324-328.
[10]	曹洁，朱亦堃，焦玉睿.CD4+T 淋巴细胞亚群与2 型糖尿病研究进展[J].新医学，2019，50（5）：319-322.
[11]	杨嘉颖，龚昱嘉，赖梦宇，等.不同病程的2 型糖尿病患者经标准化代谢性疾病管理后的代谢指标转归[J].中华内分泌代谢杂志，2021，37（2）：106-113.
[12]	王柳明，陈文凤，刘建兵，等.HCMV 感染对2 型糖尿病糖代谢的影响研究[J].中华医院感染学杂志，2019，29（10）：1500-1503.
[13]	赵长新，温江涛，李世宝，等.糖尿病患者人巨细胞病毒、柯萨奇B 组病毒和胰岛细胞抗体、谷氨酸脱羧酶抗体及空腹血糖水平的变化及其临床意义[J].中国糖尿病杂志，2015，23（6）：505-508.
[14]	刘春梅，齐学林，董晓玲，等.糖尿病患者人危险病毒因素的变化及其临床意义[J].基因组学与应用生物学，2016，35（4）：775-778.
[15]	白耀博，时艳，刘伟.人巨细胞病毒感染对2 型糖尿病患者糖代谢C 肽及胰岛素敏感性的影响[J].河北医学，2020，26（2）：252-255.
[16]	张宝玉，孙荣欣，石威，等.中性粒与淋巴细胞比值与2型糖尿病肾病的相关性[J].中国医药导报，2019，16（4）：83-87.