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| Clinical effect of Levetiracetam in the treatment of children with febrile convulsion |
| LIAO Yue-juan |
| Department of Pediatrics, Guangdong Provincial People′s Hospital, Zhuhai Hospital, Guangzhou 519000, China |
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Abstract Objective To study the clinical effect of Levetiracetam in the treatment of children with febrile convulsion.Methods Ninety-six children with febrile convulsion admitted to our hospital from May 2017 to January 2019 were selected as research objects, and they were divided into control group and observation group according to the random number table method, with 48 cases in each group. The control group was treated routinely, and the observation group was treated with Levetiracetam on the basis of the control group. The clinical efficacy and incidence of adverse reactions in the two groups were compared and analyzed. The symptom relief and levels of brain nerve related factors (neuron-specific enolase [NSE], S-100β protein [S-100β], and brain-derived neurotrophic factor [BDNF]) before and after treatment of the two groups of children were recorded. Results The total effective rate of treatment in the observation group (95.83%) was higher than that in the control group (83.33%), and the antipyretic time was earlier than that in the control group, with statistically significant differences. After treatment, the levels of NSE, S-100β and BDNF in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05).There were no significant differences in the number of fevers and the incidence rate of adverse reactions in the two groups of children (P＞0.05). Conclusion Levetiracetam in the treatment of children with febrile convulsion can significantly improve the clinical efficacy, relieve the symptoms of fever in children, greatly improve the level of brain nerve related factors, and ensure the safety of medication, and have a positive effect on the prognosis of children.
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