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| Effect evaluation and cost-effectiveness analysis on intervention of rational drug use by pharmacists in perioperative period of cesarean section |
| YAN Fei XU Wen-qing LE Liang |
| Department of Pharmacy, Jingdezhen First People′s Hospital, Jiangxi Province, Jingdezhen 333000, China |
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Abstract Objective To analyze the effect evaluation and cost-effectiveness on intervention of rational drug use by pharmacists in perioperative period of cesarean section, so as to promote rational drug use.Methods A total of 100 cases of cesarean section before the intervention (from April 2017 to March 2018) were randomly selected as the preintervention group, and 100 cesarean section cases after the pharmacist participated in the intervention (from April 2018 to March 2019) were selected as the post-intervention group for retrospective evaluation and analysis.Results After intervention, the rational rate of antibiotic selection in perioperative period increased from 75% to 93% (χ2=12.05,P=0.00), the rational rate of time points of prophylaxis use of antimicrobial increased from 79% to 95% (χ2=11.32, P=0.00), and the rational rate of medication time of the preventive application of antibacterials increased from 67% to 92% (χ2=19.18, P=0.00).The results of cost-effectiveness analysis showed that the cost-effectiveness ratio (C/E) of antibiotics decreased from 0.26 to 0.06 after intervention, and the C/E of drug costs decreased from 16.97 to 9.89 after intervention.Conclusion Both the analysis of intervention effect and the evaluation of pharmacoeconomics show that pharmacists intervention could effectively promote the rational use of antibiotics in perioperative period of cesarean section.
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