中性粒细胞明胶酶相关脂质运载蛋白在心肾综合征中的早期诊断价值

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Abstract Objective To investigate the early diagnostic value of neutrophil gelatinase-associated lipid-carrying proteins (NGAL) in cardiorenal syndrome (CRS).MethodsA total of 165 patients with heart failure (HF) who were admitted to Shangrao People′s Hospital from November 2017 to October 2018 were seleted as the research objects.According to the CRS diagnostic guidelines,38 patients with acute decompensated heart failure (ADHF) and new acute kidney injury (AKI) were selected as the CRS group,and the remaining 127 patients were assigned as the control group.The urine NGAL (uNGAL),N-terminal pro-brain natriuretic peptide (N-proBNP),cystatin (Cys-C),urea nitrogen (BUN),and creatinine (SCr) levels were compared between the two groups.The levels of uNGAL,SCr,Cys-C and BUN at 0(baseline),2,4,8,18,48 h of CRS group were detected respectively.The value of uNGAL in the diagnosis of CRS was analyzed by receiver operating characteristic (ROC) curve.Results The levels of SCr,BUN,uNGAL,Cys-C and NTproBNP in the CRS group were higher than those in the control group,and the differences were statistically significant(P<0.05).The SCr and BUN levels in the CRS group at 48 h were significantly higher than those at the baseline,and the differences were statistically significant (P<0.05).The levels of uNGAL in the CRS group at 2,4,8,18,and 48 h were significantly higher than those at the baseline,the differences were statistically significant (P<0.05),and peaked at 2 and 4 h.The Cys-C levels at 4,8,18,and 48 h in the CRS group were higher than those at the baseline,and the differences were statistically significant (P<0.05).The ROC curve analysis showed that the AUC of the diagnosis of AKI at 2,4,8,and 18 h were 0.879,0.862,0.848,and 0.813,95% CI was 0.768-0.981,0.735-0.977,0.723-0.971,and 0.741-0.954,respectively.When 169.1 ng/ml was used as the cut-off value for the diagnosis of AKI,the sensitivity and specificity were 95.61% and 87.52%,respectively.Conclusion The uNGAL is associated with AKI in patients with ADHF during hospitalization,and it is an early independent predictor of renal function deterioration during hospitalization of HF patients,which is of great significance in the early diagnosis and early intervention of CRS patients.

Key words： Neutrophil gelatinase-associated lipid-carrying proteins Cardiorenal syndrome Cystease inhibitors Urea nitrogen Creatinine Acute kidney injury

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	Articles by authors
	SONG Xing-liang
	CHENG Yan-mei
	HUANG Jun
	SHAO Xiang
	XU Jing-lan
	YAN Fei-ben

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SONG Xing-liang,CHENG Yan-mei,HUANG Jun, et al. Early diagnostic value of neutrophil gelatinase-associated lipid-carrying proteins in cardiorenal syndrome[J]. 中国当代医药, 2019, 26(27): 143-146.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2019/V26/I27/143

[1]	Ronco C，Di Lullo L.Cardiorenal syndrome[J].Heart Fail Clin，2014，10（2）：251-280.
[2]	Cruz DN，Ronco C，Katz N.Neutrophil gelatinase-associated lipocalin： a promising biomarker for detecting cardiac surgery-associated acute kidney injury[J].J Thorac Cardiovasc Surg，2010，139（5）：1101-1106.
[3]	Peacock WF，Maisel A，Kim J，et al.Neutrophil gelatinase associated lipocalin in acute kidney injury[J].Postgrad Med，2013，125（6）：82-93.
[4]	Buonafine M，Martínez-Martínez E，Amador C，et al.Neutrophil Gelatinase-Associated Lipocalin from immune cells is mandatory for aldosterone-induced cardiac remodeling and inflammation[J].J Mol Cell Cardiol，2018，115：32-38.
[5]	Thakur V，Chattopadhyay M.Early urinary markers for diabetic and lther kidney diseases[J].Curr Drug Targets，2018，19（7）：825-831.
[6]	张雅丽，崔丽艳，张捷.中性粒细胞明胶酶相关脂质运载蛋白在急性肾损伤中的保护作用[J].检验医学，2015，30（1）：80-84.
[7]	安淑娴.中性粒细胞明胶酶相关脂质运载蛋白作为急性肾损伤新的生物学标志物的研究进展[J].国际泌尿系统杂志，2012，32（1）：107-110.
[8]	冯京全，柏明见，高智勇，等.尿NGAL、KIM-1 联合检测早期诊断对比剂肾病的价值研究[J]国际检验医学杂志，2019，40（3）：355-358.
[9]	郑漾，呼传邦，莫世静，等.血液生物标志物对预测ICU 患者急性肾损伤及判断预后的价值分析[J].中国现代医生，2018，56（19）：14-17.
[10]	Hillege HL，Girbes AR，de Kam PJ，et al.Renal function，neurohormonal activation，and survival in patients with chronic heart failure[J].Circulation，2000，102（2）：203-210.
[11]	程悠悠，黄庆，叶宏伟.NGAL 和Cys-C 对脓毒症相关急性肾损伤的早期诊断意义[J].华南国防医学杂志，2016，30（8）：496-499，532.
[16]	李敏，张荣林.慢性心力衰竭老年患者血、尿NGAL 水平与心功能及预后的关系[J].南京医科大学学报（自然科学版），2016，36（10）：1496-1499.
[17]	王官容，钟洪伟，王贞美，等.uNGAL 对危重病患者早期急性肾损伤的诊断价值[J].中国预防医学杂志，2018，19（9）：700-703.
[12]	Parikh CR，Mishra J，Thiessen-Philbrook H，et al.Urinary IL-18 is an early predictive biomarker of acute kidney innury after cardiac surgery[J].Kidney Int，2006，70（1）：199-203.
[13]	Mishra J，Dent C，Tarabishi R，et al.Neutrophil gelatinaseassociated lipocalin （NGAL）as a biomarker for acute renal injury after cardiac surgery[J].Lancet，2005，365（9466）：1231-1238.
[14]	Liebetrau C，Dorr O，Baumgarten H，et al.Neutrophil gelatinase-associated lipocalin （NGAL）for the early detection of cardiac surgery associated acute kidney injury[J].Scand J Clin Lab Invest，2013，73（5）：392-399.
[15]	Mori K，Nakao K.Neutrophil gelatinase-associatedlipocalin as the real-time ind Icator of active kidneydamage[J].Kidney Int，2007，71（10）：967-970.