|
|
|
| Correlation analysis of serum lactic acid content and the degree of nerve injury and myocardial damage in children with hand-foot-mouth disease |
| CHEN Mu-rong |
| Department of Pediatrics and Internal Medicine,Maternal and Child Health Care Hospital of Jiujiang City in Jiangxi Province,Jiujiang 332000,China |
|
|
|
|
Abstract ObjectiveTo investigate the correlation between serum lactic acid content and the degree of nerve injury and myocardial damage in children with hand-foot-mouth disease.MethodsFrom June 2015 to June 2017,37 children with hand-foot-mouth disease complicated with encephalitis were enrolled as the encephalitis group.The other 58 children only with hand-foot-mouth disease at the same time were selected as the simple hand-foot-mouth disease group.The content of lactic acid in serum was determined by enzyme colorimetric method.The indexes of nerve injury and content of inflammatory factors were determined by enzyme linked immunosorbent assay (ELISA).The content of myocardial enzymes in serum was determined by radioimmunoassay.Pearson test was used to evaluate the correlation between serum lactic acid content and severity of nerve injury in children with hand-foot-mouth disease complicated with encephalitis.Results The content of lactic acid in children in the encephalitis group was higher than that in the simple hand-foot-mouth disease group(P＜0.05).The contents of neuron specific enolase(NSE),S-100B protein(S-100B),and myelin basic protein (MBP)in the encephalitis group were significantly higher than those in the simple hand-footmouth disease group (P＜0.05).Meanwhile,the levels of serum LDH,CK-MB,α-HBDH,and AST in children in the encephalitis group were higher than those in children in the simple hand-foot-mouth disease group (P＜0.05).The serum lactate content in children with hand foot and mouth disease is positively correlated with the nerve damage index NSE,S-100B and MBP(r=0.245,0.195,0.318,P＜0.05).The serum lactate content in children with hand foot and mouth disease is positively correlated with myocardial enzyme spectrum LDH,CK-MB,α-HBDH,AST (r=0.275,0.415,0.512,0.198,P＜0.05).ConclusionThe serum lactic acid level in children with hand-foot-mouth disease rises,and the indexes of nerve injury and myocardial damage also increase,which display a positive correlation,therefore,the serum lactic acid content can be used as a predictive index of nerve injury and myocardial damage in hand-foot-mouth disease.
|
|
|
|
|
|
| [1] |
岑发全.手足口病合并脑炎患儿病情严重程度与其血清、脑脊液中VEGF和VCAM-1水平的相关性分析[J].海南医学，2014，25（24）：3710-3713.
|
| [2] |
Chen F，Li J，Liu T，et al.MRI characteristics of brainstem encephalitisinhand-foot-mouthdiseaseinducedbyenterovirus type 71-will different MRI manifestations be helpful for prognosis?[J].Eur J Paediatr Neurol，2013，17（5）：486-491.
|
| [4] |
陈姣，雷智贤，陈贝贝.VCAM-1、VEGF在合并脑炎手足口病患儿中的检测意义[J].中国妇幼保健，2015，30（19）：3186-3189.
|
| [5] |
胡小平，陈杰.手足口病并发脑炎患儿免疫功能及与病情严重程度的关系研究[J].儿科药学杂志，2014，20（3）：7-10.
|
| [7] |
韦佩俭，陈浩，韦松盛.血糖与血乳酸水平在手足口病治疗中的临床意义[J].临床医学，2015，35（3）：111-114.
|
| [8] |
殷卫兵，严鸣光.病毒性脑炎患儿脑脊液和血清中NSE、MBP和S-100的变化及临床意义[J].中国卫生检验杂志，2015，25（22）：3899-3902.
|
| [9] |
吕祖芳，李明磊，张立明，等.血清特异性烯醇化酶和脑电图及颅脑磁共振成像对病毒性脑炎合并惊厥患儿预后评估价值研究[J].中国全科医学，2014，17（16）：1870-1873.
|
| [3] |
Zeng H，Wen F，Gan Y，et al.MRI and associated clinical characteristics of EV71-induced brainstem encephalitis in children with hand-foot-mouth disease[J].Neuroradiology，2012，54（6）：623-630.
|
| [6] |
NassefC，ZiemerC，MorrellDS.Hand-foot-and-mouthdisease：a new look at a classic viral rash[J].Curr Opin Pediatr，2015，27（4）：486-491.
|
| [10] |
Wang Z，Nicholls JM，Liu F，et al.Pulmonary and central nervous system pathology in fatal cases of hand foot and mouth diseasecaused by enterovirus A71 infection[J].Pathology，2016，48（3）：267-274.
|
| [11] |
卢蓉，赵力芳，贾鲲鹏，等.小儿病毒性脑炎患儿心肌酶谱、血浆超敏C反应蛋白和胱抑素C水平变化及其临床意义[J].实用心脑肺血管病杂志，2016，24（7）：77-80.
|
| [12] |
屠友权，李光乾.小儿病毒性脑炎与血清心肌酶谱的相关性分析[J].中国生化药物，2014，34（3）：122-125.
|
|
|
|
