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| The significance of the thymidylate synthase expression in therapeutic effect evaluation of Pemetrexed treating patients with advanced ovarion cancer |
| HU Yong-hua FAN Yu-fei QIN Yuan LI Ding-gang |
| Department of Oncology,Beijing Yanhua Hospital,Beijing 102500,China |
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Abstract Objective To evaluate the significance ofthe thymidylate synthase(TS)expression in therapeutic effect evaluation of Pemetrexed in patients with advanced ovarion cancer.Methods Eighty patients with advanced recurrent ovarian cancer from July 2010 to July 2014 treated in our hospital were analyzed retrospectively,all of them were treated by Pemetrexed combined with Nedaplatin,the experimental group had 40 cases,their tumor tissue were detected by immunohistochemistry with TS negative expression,the control groups of 40 cases with unknown TS expression.The therapeutic effectwas analyzed.Results In experimental group,there were 2 cases achieved complete responses(CR)of the 40 cases, 21 cases achieved partial response(PR),8 cases achieved stable disease(SD)and 9 patients with progressive disease(PD), while in observation group,there was 1 case achieved CR of the 40 cases,13 cases achieved PR,7 cases achieved SD and 19 patients with PD,while in experimental group,the overall response rate,the disease control rate and one year survival rate were 57.5%,77.5%and 60.0%respectively,in observation group,it was 35.0%,52.5%,37.5%respectively,and there was a statistical difference between two groups(P＜0.05).Conclusion TS expression may serve as an indicator to predict the sensitivity of chemosensitivity to Pemetrexed in patients with advanced ovarian cancer,the negative expression of TS can benefit from chemotherapy with Pemetrexed.
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