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| Analysis of the efficacy and safety of small amount of Mannitol combined with Bumetanide in the treatment of elderly patients with acute massive cerebral infarction with cerebral edema |
| ZHANG Yan-ying1 SHI Zhen-dong2▲ |
1.Department of Neurology,Tiefa Coal Industry Group General Hospital Affiliated to Shenyang Medical College,Tieling 112700,China;
2.VIP Ward,Tiefa Coal Industry Group General Hospital Affiliated to Shenyang Medical College,Tieling 112700,China |
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Abstract Objective To evaluate the efficacy and safety of small amount of Mannitol combined with Bumetanide in the treatment of elderly patients with acute massive cerebral infarction with cerebral edema.Methods 106 elderly patients with acute massive cerebral infarction with cerebral edema in our hospital fron January 2010 to December 2015 were selected and divided into the study group(54 cases)and the control group(52 cases)by random number table method. The study group was treated with low dose Mannitol 2 times daily dosing and combined Bumetanide,the control group was treated with low-dose Mannitol daily for 3 times.Antiplatelet aggregation,brain protection,lipid-lowering,stable atherosclerotic plaques and other neurological routine treatment were given in the two groups.The clinical efficacy and adverse reactions of the two groups were observed.Results The total effective rate of the study group and the control group were 87.0%and 88.4%,respectively.There was no significant difference between the two groups (P＞0.05).The total incidence rate of adverse reactions in the study group was 18.5%,which was lower than that of the control group (30.8%),with significant difference(P＜0.05).Conclusion Small amount of Mannitol combined with Bumetanide treatment in elderly patients with acute massive cerebral infarction with cerebral edema is more reasonable,and good safety.
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