|
|
Correlation study of insulin resistance and carotid intima-media thickness in diabetes mellitus/non-diabetes mellitus patients with peritoneal dialysis |
YANG Guang1 LI Xiao-yan2▲ PENG Hong-xia1 |
1.Department of nephrology,People′s Hospital of Ganzhou City in Jiangxi Province,Ganzhou 341000,China;
2.Department of Endocrinology,People′s Hospital of Ganzhou City in Jiangxi Province,Ganzhou 341000,China |
|
|
Abstract ObjectiveTo explore the correlation between insulin resistance and carotid intima-media thickness in diabetes mellitus(DM)/non-DM patients with peritoneal dialysis.MethodsFrom June 2016 to June 2017,56 end-stage renal disease(CHD)patients with DM/non-DM who were performed with peritoneal dialysis in our hospital were selected. There were 28 cases with DM and the rest were not occurred with DM.According to insulin resistance or not,they were divided into insulin resistance group and non-insulin resistance group.The correlation of insulin resistance and carotid intima-media thickness in the two groups was compared.ResultsFor DM patients,insulin resistance had positive correlations with 2 h PBG,CIMT,LDLC,TG and hs-CRP(P<0.05).In the non-DM group,insulin resistance was positively correlated with 2 h PBG,CIMT,HbA1c,LDLC,TG and hs-CRP(P<0.05).ConclusionInsulin resistance in DM/non-DM patients is both positively correlated with 2 h PBG,CIMT,LDLC,TG and hs-CRP,which indicates insulin resistance can promote the thickening of carotid intima-media thickness.
|
|
|
|
|
[1] |
李建英,梁青,黄克基,等.腹膜透析营养不良患者中医证型与胰岛素抵抗的关系及相关因素分析[J].世界中西医结合杂志,2011,6(10):859-861.
|
[2] |
武蓓,赵慧萍,芦丽霞,等.非糖尿病腹膜透析患者胰岛素抵抗改变及其影响因素[J].中华肾脏病杂志,2015,31(4):251-255.
|
[3] |
Rubio-Guerra AF,Cabrera-Miranda LJ,Vargas-Robles H,et al.Correlation between levels of circulating adipokines and adiponectin/resistin index with carotid intima-media thicknessinhypertensivetype2diabeticpatients[J].Cardiology,2013,125(3):150-153.
|
[4] |
官继超,龚淑文,吴秀娟,等.黄芪联合替米沙坦对非糖尿病腹膜透析患者胰岛素抵抗的影响研究[J].中国全科医学,2015,18(30):3717-3721.
|
[5] |
官继超,寿张飞,谢海英,等.替米沙坦对非糖尿病腹膜透析患者胰岛素抵抗及残余肾功能的影响[J].中国老年学杂志,2016,36(2):325-327.
|
[6] |
Pacifico L,Bonci E,Andreoli G,et al.Association of serum triglyceride-to-HDL cholesterol ratio with carotid artery intima-media thickness,insulin resistance and nonalcoholic fatty liver disease in children and adolescents[J].Nutr Metab Cardiovas,2014,24(7):737-743.
|
[7] |
刘海军.腹膜透析患者血清脂联素与胰岛素抵抗的关系[J].南昌大学学报(医学版),2013,53(5):49-51,106.
|
[8] |
赵俊丽,丁发贤,王娟丽,等.非糖尿病腹膜透析患者胰岛素抵抗与颈动脉粥样硬化的相关性[J].中国动脉硬化杂志,2016,24(4):401-404.
|
[9] |
陈秀锋,路建饶,王新华,等.应激信号通路参与非糖尿病腹膜透析患者的胰岛素抵抗[J].中国综合临床,2014,30(5):527-529.
|
[10] |
Peng H,Zhong M,Zhao W,et al.Urinary miR-29 correlates with albuminuria and carotid intima-media thickness in type 2 diabetes patients[J].PloS One,2013,8(12):e82607.
|
[11] |
曾海鸥,袁丽萍,罗敏虹,等.血液透析和腹膜透析对非糖尿病终末期肾病患者胰岛素抵抗、微炎症状态及脂质代谢的影响[J].临床医学,2016,36(1):32-34.
|
[12] |
Tarantino G,Finelli C,Colao A,et al.Are hepatic steatosis and carotid intima media thickness associated in obese patients with normal or slightly elevated gamma-glutamyltransferase[J].J Transl Me,2012,10(1):50.
|
[13] |
倪军.非糖尿病维持性腹膜透析患者胰岛素抵抗的临床研究[D].杭州:浙江大学,2013.
|
[14] |
曾海鸥,陈圳炜,罗敏虹,等.透析方式对非糖尿病终末期肾脏病患者临床指标及胰岛素抵抗影响的比较[J].中国血液净化,2016,15(4):219-225.
|
[15] |
贾婧.腹膜透析患者维生素D水平对胰岛素抵抗、血脂异常的影响[D].苏州:苏州大学,2011.
|
|
|
|