咪达唑仑和芬太尼联合应用在危重患者机械通气镇静、镇痛治疗中的效果及安全性

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Abstract ObjectiveTo explore the Efficency and safety of Midazolam combined with Fentanyl in sedation and analgesia of critically severe patients with mechanical ventilation.Methods122 cases of severe patients undergoing mechanical ventilation in our hospital from December 2014 to December 2016 were selected and divided into experimental group and control group,with 61cases in each group.The control group was used Midazolam for sedation before intubation.The experimental group was used Fentanyl on the basis of control group.The onset time,wake up time,the degree of patient distress and 24 h after mechanical ventilation,the blood pressure,heart rate,RP,SpO2,SpO2/FiO2of patients and were compared between two groups.ResultsThe onset time and wake up time[(49.3±8.7)s,(20.2±6.2)min]in experimental group were shorter than those in control group [(85.6±12.7)s,(39.2±8.9)min],the BPS score of experimental group [(2.4±1.0)points]was lower than that in control group[(5.2±2.4)points],the levels of heart rate and PR[(75.3±6.6),(14.2± 3.5)times/min]of patient in experimental group were lower than those in control group[(84.1±7.8),(18.8±4.1)times/min], the SpO2,SpO2/FiO2in experimental group[(97.1±2.5)%,(256.4±25.6)mmHg]were higher than those in control group [(92.2±3.3)%,(209.8±30.8)mmHg],the total incidence of adverse reaction in experimental group(21.31%)was lower than that in control group(61.85%).All the differences were statistically significant(P<0.05).ConclusionMidazolam combined with Fentanyl in mechanical ventilation sedation and analgesia of critically ill patients with advantages of short onset time,fast wake up,significantly reducing the pain of patients,and has less affect on heart rate and respiratory rate.It is worthy to popularize.

Key words： Midazolam Fentanyl Mechanical ventilation

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	ZHANG Hong-mei
	REN Wei-hong
	YAO Yu-ling

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ZHANG Hong-mei,REN Wei-hong,YAO Yu-ling. Efficency and safety of Midazolam combined with Fentanyl in sedation and analgesia of critically severe patients with mechanical ventilation[J]. 中国当代医药, 2017, 24(12): 90-92.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I12/90

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