外源性硫化氢对大鼠静脉移植物内膜增生的影响

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Abstract Objective To investigate the effect of hydrogen sulfide on intimal hyperplasia in the rat vein grafts.M ethods External carotid vein transplantation model of rats was established，24male rats were randomly divided into the control group and experimental group，each group of 12，the experimental group was given the administration of the hydrogen sulfide donor NaHS，control group was given the same dose of normal saline，2 weeks and 4 weeks after excision of transplanted vein respectively，computer image analysis system was used tomeasure intimal and medial thickness in the endometrium was calculated，mmunohistochemicalmethod was used to detect vein graft smoothmuscle cell proliferation nucleus（PCNA）expression，statistical analysis of all rats intimal thickness and intimal sectional area，the PCNA index was given.Results Two groups of VG were kept unobstructed，at the time of taking no thrombosis and occlusion，the experimental group and control group of vein grafts in endometrium and the thickness of themembrane after surgery were significantly increased，while the experimental group in the endometrium，compared with control group，intimal thickness 2 weeks and 4 weeks after surgery was increased lighter，with significant difference（P＜0.05）；the two groups of VG in the PCNA positive cellsmainly distributed in near the lumen side and innermembranes in VG PCNA index after surgery，in the experimental group and control group were reduced obviously，and compared with control group，the experimental group in the endometrium，intimal thickness，2 weeks and 4 weeks after surgery was reduced lighter，with significant difference（P＜0.05）.Conclusion Exogenous hydrogen sulfide can effectively restrain the aortic smooth muscle cell proliferation and promote its apoptosis，inhibition of vein graft intimal hyperplasia，it is advantageous to the prevention of the occurrence of restenosis bridge，it isworth clinical for further promotion.

Key words： Hydrogen sulfide Vein graft Intimal hyperplasia

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	Articles by authors
	YANG Hong-wei
	WANG Zu-hui
	CHEN Heng
	ZHU Guo-xian
	LITao
	TAN Yi-hua

Cite this article:

YANG Hong-wei,WANG Zu-hui,CHEN Heng, et al. Effect of hydrogen sulfide on intimal hyperp lasia of vein grafts in the rat[J]. 中国当代医药, 2016, 23(21): 8-10.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I21/8

［1］	Mark MP，Christopher KH，Matthew W，et a l.Hydrogen sulfide inhibits proliferation and release of IL-8 from human airway smooth muscle cells［J］.Am JRespir Cell Mol Biol，2011，45（4）：746-752.
［2］	张远达，冀超玉，王静，等.川崎病患儿硫化氢与白细胞介素1β、白细胞介素6水平的变化及其相关性［J］.中华实用儿科临床杂志，2015，30（21）：1676-1677.
［3］	于文，金红芳.气体信号分子硫化氢血管调节作用的研究进展［J］.转化医学杂志，2013，2（14）：227-231.
［4］	周红，梁小，吴晓燕，等.不同剂量硫化氢抗大鼠动脉粥样硬化的研究［J］.中国现代医学杂志，2013，23（27）：1-5.
［5］	陈斯瑶，金红芳，孙燕，等.二氧化硫对低氧性肺动脉高压大鼠内源性硫化氢体系的调节作用［J］.中华儿科杂志，2011，49（12）：890-894.
［6］	郭鸿鸣，肖天宇，谢彦杰.气体信号分子硫化氢在植物中的生理功能及作用机制［J］.中国生物化学与分子生物学报，2016，32（5）：488-495.
［7］	汪金丽，沈兵，范一菲，等.NaHS对慢性间歇性低氧大鼠胸主动脉血管张力的影响［J］.安徽医科大学学报，2016，51（3）：329-332.
［8］	贾静，何江波，曾韦锟，等.外源性硫化氢对心肌肥大的保护作用［J］.国际心血管病杂志，2015，42（6）：403-406.
［9］	乔伟丽，杨文学，刘磊，等.外源性硫化氢减轻D-半乳糖诱导的亚急性衰老大鼠血管老化［J］.生理学报，2014，66（3）：276-282.
［10］	Richard SB，Shawn EB.Vascular complications of cystathionineβ-synthase deficiency：future directions for homocysteine-to-hydrogen sulfide research［J］.Am JPhysiol Heart Circ Physiol，2011，300（1）：H13-H26.
［11］	强俊叶，翟瑶，张静，等.外源性硫化氢对足月妊娠子宫平滑肌收缩功能的影响［J］.中国医药导报，2016，13（5）：95-98.
［12］	宋志强，张建鹏.硫化氢对血管平滑肌细胞的影响［J］.生物技术通讯，2015，26（6）：871-875.
［13］	Huang W，Chen S，Li XL，et al.The role of endogenous hydrogen sulfide（H2S）in the rats with diabetic nephropathy（DN）［J］.JCapital Univ Med Sci，2015，36（3）：505-507.
［14］	袁平，王丽丽，王岚，等.硫化氢供体对低氧大鼠肺动脉平滑肌细胞小窝蛋白的影响［J］.中华老年多器官疾病杂志，2015，14（12）：923-928.
［15］	全晓静，罗和生，陈炜，等.一氧化氮和硫化氢对大鼠结肠平滑肌钙钾电流影响的比较［J］.中华实验外科杂志，2015，32（12）：3053-3057.
［16］	兰丽，吉散，季晖.硫化氢对抗脑缺血再灌注损伤的机制研究进展［J］.药学进展，2016，40（4）：293-298.